Four researchers honored by AAAS as Lifetime Fellows
Grant and Award Announcement
Updates every hour. Last Updated: 10-Sep-2025 16:11 ET (10-Sep-2025 20:11 GMT/UTC)
A powerful AI model called Deep Novel Mutation Search (DNMS) predicts virus mutations more accurately and efficiently than traditional, time-consuming lab experiments. Focused on the SARS-CoV-2 spike protein, the model uses a specialized protein language model fine-tuned to understand the virus's specific “language.” DNMS can predict mutations that cause small, functional changes – crucial for viruses like SARS-CoV-2, which evolve through subtle adjustments to maintain function. This approach promises to enhance virus tracking and public health by predicting mutations more accurately and quickly.
In vertebrates, the skeleton of different regions of the body arises from different precursor cells. Researchers at the University of Basel have now discovered that these skeletal cells do not just differ in their developmental origin, but also in their gene regulation – which may be a key to the vertebrates’ evolutionary success story.
Molecular biologist Yali Dou, PhD, holder of the Marion and Harry Keiper Chair in Cancer Research and professor of medicine and cancer biology at the Keck School of Medicine of USC, has been elected a fellow of the American Association for the Advancement of Science (AAAS). She is one of seven USC faculty members in the 2025 cohort of new fellows. Dou, the associate director for basic research at USC Norris Comprehensive Cancer Center, is a recognized leader in the study of epigenetics, the mechanisms that enable the singular instructions in DNA to be expressed as myriad cell and tissue types. She has made major contributions to the fundamental understanding of a family of enzymes that plays a vital role in fetal development by altering the coiled chromatin, which packages DNA to fit in the chromosomes of a cell’s nucleus, so that genes are activated. Because mutations of the founding member of this family of enzymes can also spur leukemia, they are known as mixed-lineage leukemia proteins, or MLL. MLL enzymes are among the most frequently mutated genes in cancer.