Brazilian researchers have discovered why the guardian of the genome, p53, is uniquely prone to structural failure compared to its more robust relatives. The study identifies molecular gaps and structural frustration that trigger p53 cancer-linked aggregation, revealing how the protein sequence balances flexibility with vulnerability. These findings, stemming from over twenty years of research, provide a new roadmap for next-generation cancer therapies focused on stabilizing this critical protein.

The study identified cultivars that maintain high productivity and resilience against attacks from the disease, paving the way for more sustainable cultivation in the region. An increase in production of up to 32% was observed in varieties with high adaptive capacity and strengthened by nutrition that ensures vigor and resistance, compared to varieties more susceptible to the fungus.

Despite its popularity, researchers at São Paulo State University found no significant effects on inflammatory markers in the body after reviewing studies on the supplement.

In ten years, levels of this type of pollution in São Paulo, Brazil, reached more than four times the limit recommended by the World Health Organization.

Research conducted by a FAPESP-supported center paves the way for producing chemical inputs widely used in industry, such as in medicines and cosmetics, where they act as active ingredients or stabilizers.