https://doi.org/10.1016/j.apsb.2025.04.018

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALKBH3-regulated m¹A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells.

https://doi.org/10.1016/j.apsb.2025.04.006

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery.

BU researchers have now discovered that exosomes—messenger nanovesicles  that carry proteins, RNA, and other molecules to other cells—released into the blood by different organs and tissues in obese, insulin-resistant models, carry signals that turn otherwise slow-moving TNBC cells into highly mobile, invasive cells. This is the first time a study has shown that exosomes from an obese, diabetic environment directly cause this aggressive change in TNBC, and that Rho-proteins (molecular switches that turn “on” or turn “off” signal transduction pathways) play a key role in driving the change.