From passive to intelligent: Bioengineered organs meet electronics
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Dec-2025 00:11 ET (30-Dec-2025 05:11 GMT/UTC)
In a major advance for patients with Crohn’s disease, a new study led by researchers at Mount Sinai Health System found that guselkumab, a medication with a mechanism of action that is new to inflammatory bowel disease (IBD) treatment, outperformed an established standard of care in promoting intestinal healing and symptom relief.
A University of Calgary led study offers evidence that children with frequent and recent vomiting from an intestinal infection should be provided with two doses of ondansetron, a well-tolerated and safe anti-nausea drug, at the time of discharge from the emergency department (ED).
Most children seeking ED care due to vomiting are discharged home. Although they usually feel better when they leave the ED, the vomiting recurs in nearly one-third of children.
Dr. Stephen Freedman and his team conducted a double-blind randomized clinical trial in six pediatric hospitals in Canada. They enrolled more than 1,000 children aged six-months to 18 years. In the study, published in The New England Journal of Medicine, children administered ondansetron were less likely to have moderate-to-severe symptoms after ED discharge.
The roadmap heralds a significant increase in publicly accessible compute capacity. Investments include up to £2 billion to deliver a holistic and user-centred compute ecosystem with £1 billion to expand the AI Research Resource 20-fold by 2030.
Guoping Li, PhD, of the Department of Anesthesia, Critical Care & Pain Medicine at Massachusetts General Hospital, is the lead author and Saumya Das, MD, PhD, of the Cardiovascular Research Center at Massachusetts General Hospital, is the senior author of a paper published in Science, “A hypoxia-responsive tRNA-derived small RNA confers renal protection via RNA autophagy.”