Stopping HRT leads to a period of higher risk of bone fracture for most women
Peer-Reviewed Publication
Updates every hour. Last Updated: 20-Dec-2025 10:11 ET (20-Dec-2025 15:11 GMT/UTC)
A new study has found that the bone fracture protection women get from menopausal hormone therapy (MHT, also known as HRT) disappears within a year of stopping treatment.
In the new study, published in Lancet Healthy Longevity, experts from the School of Medicine at the University of Nottingham, also found that in most cases, stopping treatment is then followed by some years of elevated fracture risk compared to women who have never used MHT. Fracture risks then falls to be similar to, and then lower than women who have never used MHT.
The study was funded by the National Institute for Health and Care Research (NIHR) SPCR.
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