Patient care technology disruptions associated with the CrowdStrike outage
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Updates every hour. Last Updated: 16-Dec-2025 22:11 ET (17-Dec-2025 03:11 GMT/UTC)
In a paper published in Science Bulletin, the research team led by Professor Wen Zhang from the Department of Rheumatology and Immunology at Peking Union Medical College Hospital (PUMCH) has made significant progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD). The study, for the first time, demonstrates that the overexpression of early growth response factor-1 (EGR1) in epithelial cells is a core driver promoting the characteristic tissue fibrosis of the disease, laying a scientific foundation for developing potential targeted therapies.
Vaccination of pregnant women int he UK has been linked to a drop in newborns being admitted to hospital with a serious lung infection, research suggests.
A team from The University of Osaka found that the intestinal flora works together with the OTUD3 and STING genes to aggravate ulcerative colitis, a disease with no cure that causes major intestinal pain and bloody diarrhea. When the OTUD3 gene is mutated, microbes in the intestinal flora trigger STING signalingOTUD, leading to inflammation in the colon. The intestinal flora and STING signaling may be important new targets for ulcerative colitis treatment.
New Haven, Conn. — Hypertensive disorders in pregnancy (HDP) — like chronic or gestational hypertension, preeclampsia, and eclampsia — are among the leading causes of maternal and infant death in the United States.
Between 2017 to 2019, 16% of all U.S. pregnancies were complicated by an HDP diagnosis, with much higher rates seen among non-Hispanic Black/African Americanand American Indian/Alaskan Native women. But HDPs don’t just affect women in the short term; these disorders can increase their long-term risk for heart disease, kidney disease, and stroke.
But there could be an opportunity to mitigate these longer-term health risks through breastfeeding, Yale researchers have found. In a new study, they discovered that an HDP diagnosis before or during pregnancy related to higher odds of never breastfeeding, or for those who initiated breastfeeding, higher probability of stopping. The findings suggest women with HDPs may benefit from targeted interventions that promote their exposure to the cardioprotective benefits of breastfeeding.