Salk Institute scientists identified dozens of potential microproteins involved in fat cell biology in a mouse model and, in the process, validated the use of CRISPR genetic screening as an effective tool for finding microproteins in all cell types. The new fat cell microproteins may be targets for future therapeutics that treat obesity and other metabolic disorders.

A new publication offers an extensive examination of clubfoot, a congenital deformity known as congenital talipes equinovarus (CTEV), affecting about 0.3% of all live births. Clubfoot is characterized by the inward rotation of the foot, often causing significant mobility challenges if not treated early. The article explores the underlying genetic factors, epidemiological patterns, and current management techniques associated with this condition.