A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment.

Hundreds of thousands of people undergo corrective eye surgeries each year, including the laser-assisted technique known as LASIK. But the procedure involves cutting away tissue, which can result in negative side effects, prompting researchers to develop a less invasive technique that takes the laser out of LASIK by remodeling cornea tissue, rather than removing it, in initial animal tissue tests. The researchers will present their results at ACS Fall 2025.

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a lack of Polβ leads to a significant increase in small insertions and deletions of DNA, known as indels near CpG sites, which are important regulatory regions in genes. This accumulation of mutations could contribute to neurodevelopmental disorders.