Relevance exists between tumorigenesis and embryonic development. Distinct clinical and molecular features, as well as the relationship between the pattern of lymphoma invasion and germ layer development remain largely unknown. Researchers identified a germ layer-dependent specification of extranodal invasion (ENI) in diffuse large B-cell lymphoma. Upon R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) treatment, mesoderm-originating ENI (ENI-mesoderm) was significantly associated with inferior progression-free survival and overall survival, as compared to ectoderm-originating ENI (ENI-ectoderm) and endoderm-originating ENI (ENI-endoderm). Representative oncogenic mutations were MYD88, PIM1, and TBL1XR1 in ENI-ectoderm, TP53 and TET2 in ENI-endoderm, and MYD88, PIM1, TBL1XR1, and CD79B in ENI-mesoderm. Notably, organotrophic migration exhibited temporal disparities corresponding to germ layer development, occurring from ectoderm- to endoderm- and mesoderm-originating organs, with a similar trajectory to the germ layer process. Single-cell RNA sequencing revealed that malignant B cells follow a developmental trajectory mirroring the germ layer process, differentiating from a progenitor state enriched with NF-κB and T-cell activation signaling into two distinct branches by either upregulated B-cell receptor signaling (Path I) or sustained T-cell activation (Path II). Regarding immune checkpoints, ENI-ectoderm, ENI-endoderm, and ENI-mesoderm exhibited significant upregulation of LGALS9, PD-L1, and B7-H3, respectively. Their findings thus contributed to a better understanding of crosstalk between lymphoma progression and embryonic development, providing new insights into targeted approaches against germ layer-dependent invasion in cancer treatment.

In the high-stakes world of drug discovery, building a new medicine is a lot like microscopic architecture. To create the next breakthrough antibiotic or brain-targeting therapy, chemists must snap together fragile molecular building blocks. But for decades, one of the most useful chemical pieces has been notoriously stubborn, requiring conditions so harsh they often destroy the very medicine being built. Now, researchers have found a way to pick the lock.

When in life we gain weight can have a significant impact on our health many years later. In a study involving over 600,000 people, researchers at Lund University in Sweden have investigated how changes in weight between the ages of 17 and 60 are linked to the risk of dying from various diseases. The results show a clear pattern: weight gain early in adulthood has the greatest impact. 

Scripps Research has received more than $500,000 in first-year funding of a five-year R01 grant worth a total of approximately $4.2 million from the National Institutes of Health (NIH) to advance technologies for studying viral proteins and antibody responses, tools that could aid the design of vaccines against deadly pathogens like HIV. The first year of funding totals $511,531, with the NIH expected to provide $918,223 annually in subsequent years, pending the availability of funds.

A recent session of the Carbon and Soil Research International Forum brought together leading scientists to address a critical challenge in sustainable agriculture: how to improve soil health while maximizing carbon sequestration. The 22nd installment of the forum was held online on March 11, 2026, and is now available for public viewing via a recorded presentation on YouTube.