10-Jul-2025
Hypothermia alters glucose metabolism and may reveal mechanisms of metabolic disease
National Institutes of Natural SciencesPeer-Reviewed Publication
The low body temperatures observed during hibernation are associated with lower metabolism. The conventional view in biology has been that body temperature is simply a consequence of metabolic activity, and that as metabolism lowers, body temperature decreases in parallel. Researchers recently discovered that low body temperature directly regulates glucose metabolism in hypothermic mice, challenging the theory of metabolic regulation of body temperature during hibernation and torpor, a less intense form of hibernation.
- Journal
- Nature Communications
- Funder
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT)/Japan Society for the Promotion of Science (MEXT/JSPS), Advanced Bioimaging Support, Japan Agency for Medical Research and Development (AMED) Brain/MINDS and Brain/MINDS 2.0, NINS program of Promoting Research by Networking among Institutions, Joint Research Program of the National Institute for Physiological Sciences, Joint Researc of the Exploratory Research Center on Life and Living Systems (ExCELLS)