Professor Ogawa, Mr. Echigo (PhD student), and their colleagues in Kanazawa University report in Eur J Nucl Med Mol Imaging that combination of an At-211-labeled agent with immune checkpoint blockade significantly enhances its therapeutic effect. This strategy represents a promising advancement in the development of next-generation cancer therapies that combine targeted alpha therapy and immunotherapy.

Innovation Center of NanoMedicine (iCONM), in collaboration with Prof. Takahiro Nomoto's Lab at the University of Tokyo, will hold a seminar on drug design and rationalization of treatment protocols for photodynamic therapy (PDT) based on singlet oxygen imaging on September 19, at 1:30 pm. This is based on a Japan-Germany Bilateral Collaboration Research between DAAD (German Academic Exchange Service) and JSPS (Japan Society for the Promotion of Science), with the aim of expanding the framework for joint research on the topic PDT and stimulating its international collaboration.

Researchers from The University of Osaka used electricity to drive a reaction to form a novel hetero[8]circulene consisting of five hexagons and three pentagons (called a dioxaza[8]circulene). The dioxaza[8]circulene is unsymmetrical, unlike existing hetero[8]circulenes. The novel molecule can be produced from commercially available materials by a two-step method that simultaneously forms six new bonds with only water as a byproduct. The dioxaza[8]circulene may have potential as a photocatalyst, and be used to speed up reactions triggered by light.

Nanoporous metal oxides have a wide variety of applications, such as catalysts, electrodes, energy materials, sensors, and biomaterials. Recently, a team of researchers has demonstrated a novel synthesis method for their efficient and desirable preparation. Specifically, they prepared difficult-to-prepare quasi-single-crystalline inverse opal α-Fe₂O₃, demonstrating that crystal growth occurs in nanospace due to volatilization and oxidation of metal chlorides. This technology is expected to further the development of catalytic and energy conversion materials for carbon neutrality.

Until recently, the color variations observed in the petals of Saintpaulia were attributed to periclinal chimera or the influence of genetically distinct cell layers. Now, a new study by researchers from Japan has identified a single gene called SiMYB2 that regulates petal colors in Saintpaulia by producing two distinct mRNA transcripts. This study lays the foundation for future horticulture-related research and can aid the deliberate breeding of patterned flowers.

The subducted oceanic crusts are regarded as the major source of lower-mantle heterogeneity. However, the limited knowledge about the physical properties of major components in the subducted oceanic crusts prevents us from fully understanding the complex features of the related geophysical anomalies. Here, we comprehensively investigated the phase transition of (Al, H)-bearing stishovite at simultaneously high P-T conditions. These results contribute to our understanding on the complex depth distribution of the mid-lower mantle seismic scatterers.

A research group led by The University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a lack of Polβ leads to a significant increase in small insertions and deletions of DNA, known as indels near CpG sites, which are important regulatory regions in genes. This accumulation of mutations could contribute to neurodevelopmental disorders.