"Nanoreactor" cage uses visible light for catalytic and ultra-selective cross-cycloadditions
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Dec-2025 12:11 ET (16-Dec-2025 17:11 GMT/UTC)
While molecular cages offer high selectivity, previous versions lacked visible-light sensitivity, hindering their use in mild photochemical synthesis. We engineered a platinum(II)-based M6L4 cage that acts as a visible-light-responsive nanoreactor, achieving perfect stereo- and site-selective cross-[2+2] cycloadditions of inert substrates. This innovation enabled the first catalytic cross-[2+2] cycloaddition using supramolecular confinement, opening new avenues for highly controlled, light-driven organic synthesis.
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