Silkworm silk's hidden conductor: How sericin orchestrates fibroin into ordered nanofibrils
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 02:17 ET (26-Oct-2026 06:17 GMT/UTC)
Researchers from Zhejiang University and The Chinese University of Hong Kong have discovered that silk sericin—long considered a mere glue coating silk fibers—actively orchestrates the self-assembly of silk fibroin into ordered nanofibrils. Published in Science Bulletin, the study shows that sericin drives liquid-liquid phase separation to create dynamic micro-compartments that concentrate, stabilize, and guide fibroin proteins through a multi-stage maturation process. The findings provide a new mechanistic framework for silk fiber formation and offer design principles for bioinspired programmable materials.
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