Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Nov-2025 04:11 ET (14-Nov-2025 09:11 GMT/UTC)
Researchers integrated machine learning with multi-tiered validation to identify FDA-approved non-lipid-lowering drugs with lipid-modifying potential. From 3,430 drugs screened, 29 candidates emerged. Clinical data and mouse studies confirmed four drugs significantly improved lipid profiles. Molecular docking revealed novel binding mechanisms to targets. This approach accelerates drug repurposing, offering new options for hyperlipidemia patients unresponsive to conventional therapies.
We analyzed fungal communities in kidney tumors from 1,044 patients across four international studies. Patients with abundant tumor fungi had worse survival outcomes and reduced response to immunotherapy. These fungi may suppress fat breakdown processes and weaken immune T cells that fight cancer. We developed predictive tools using fungal signatures that accurately forecast treatment success in kidney and other cancers. One fungal species, Aspergillus tanneri, was particularly linked to poor outcomes.
The limitations of conventional electromagnetic wave (EMW) absorbing materials in terms of high-temperature resistance have stimulated interest in the development of high-temperature EMW absorbing materials across various fields. However, due to the temperature dependence of the permittivity, achieving effective EMW absorption across a wide temperature range remains a significant challenge for high-temperature EMW absorbing materials. Herein, a novel molecular-scale strategy is proposed for in-situ construction multi-heterointerface during the polymer-derived ceramics process, thereby achieving temperature-insensitive permittivity. This approach to developing temperature-insensitive dielectric ceramics significantly improves the performance and functionality of high-temperature EMW absorbing materials, thereby providing substantial guidance and reference value.
Dissolved organic matter (DOM) plays a critical role in nutrient cycling and microbial dynamics across ecosystems, but its complexity poses major analytical challenges. To address this, a team led by Prof. Jianjun Wang from the Chinese Academy of Sciences has developed iDOM, a powerful new R package for the statistical analysis and visualization of DOM data. Designed to integrate DOM composition with environmental and microbial factors, iDOM enables researchers to unravel the ecological processes driving DOM dynamics under global change. With tools for trait analysis, diversity metrics, network inference, and temperature response modeling, iDOM offers a robust and reproducible framework for DOM studies worldwide.
Second primary cancers (SPCs) are a major cause of death among cancer survivors. This review highlights recent advances in understanding SPC mechanisms, including genomic changes, stromal cell alterations, hormone signaling, immunosuppression, and gene methylation. It also explores emerging tools such as intratumoral microbes, single-cell multi-omics, and metabolomics, offering new directions for future research.
Artificial intelligence (AI) is transforming healthcare across multiple fields, and prostate cancer (PCa) is no exception. A recent review conducted by researchers discusses the role of AI in clinical practice against PCa. According to this study, AI models enable early detection of PCa with high accuracy while minimizing errors. AI models used in molecular subtyping and precision medicine also offer personalized treatments—improving the overall quality of life of patients.
This study addresses the critical gap in epidemiological data on antenatal depression in China, a condition that profoundly impacts maternal and infant health. Conducted as a cross-sectional survey from December 2019 to March 2023, the research enrolled 100,200 pregnant women across 27 hospitals in 11 provinces, municipalities, and autonomous areas. Late-pregnancy depressive symptoms were evaluated using the Edinburgh Postnatal Depression Scale (EPDS). This survey reveals that the overall prevalence of possible depression (EPDS >9) was 25.8%, and probable depression (EPDS >12) was 11.4%, with significant regional variation (highest in North China, lowest in East China). Young maternal age, low education levels, low family income, unemployment, living alone, unmarried/divorced status, unintended pregnancy, multiple pregnancy, insufficient social support, tobacco/alcohol use, and poor sleep quality were identified as risk factors for antenatal depression. Notably, family support, particularly from partners, emerges as a pivotal intervention target for reducing antenatal depression risk.
Professor Chuang Yu from Huazhong University of Science and Technology significantly enhanced the air stability of chlorine-rich Li₅.₅PS₄.₅Cl₁.₅ electrolyte and improved the electrochemical performance of all-solid-state lithium metal batteries through a phosphate group doping strategy.