Team’s sequential control policy framework offers high success in multiple peg-in-hole assembly tasks
Peer-Reviewed Publication
Updates every hour. Last Updated: 6-May-2025 16:09 ET (6-May-2025 20:09 GMT/UTC)
A research team conducted a study to improve robots' performance in multiple peg-in-hole assembly in adapting to different working scenarios, including different object geometry and pose. Using a flexible and reusable sequential control policy framework, they explored how to apply artificial intelligence technology more efficiently in industrial scenarios. Their sequential control policy framework demonstrated higher training efficiency with faster convergence and a higher success rate compared to the single control policy for long-term multiple peg-in-hole assembly tasks.
The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections. Herein, we investigate the functional role of Cullin-3 (Cul3), one critical constituent of cullin-RING ubiquitin ligases, in the Drosophila melanogaster (fruit fly) antimicrobial immune defense. We show that silencing of Cul3 leads to a decreased induction of antimicrobial peptides and high mortality in adult flies after bacterial infection. Through biochemical approaches, we demonstrate that Cul3 predominantly relies on its BTB-binding domain and neddylation domain to physically associate with death-associated inhibitor of apoptosis 2 (Diap2). Importantly, Cul3 ameliorates the Diap2-mediated ubiquitination of death-related ced-3/Nedd2-like caspase (Dredd), a process essential for robust immune deficiency signaling upon bacterial infection. Taken together, our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense, providing potential insights into therapeutic strategies for combating bacterial infections in humans.
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