This study reports two cryo-EM structures of the Nipah virus (NiV) polymerase L-P complex in its full-length and truncated forms. These structures elucidate the RNA-dependent RNA polymerase (RdRp) and polyribonucleotidyl transferase (PRNTase) domains of the L protein, as well as the tetrameric P protein bundle bound to the L-RdRp. This work establishes a foundational framework for understanding the NiV polymerase mechanism and provides critical insights for the rational design of antiviral therapeutics targeting the polymerase complex  

The study analyzed mitochondrial profiling across 22 tissues in mice and 45 human tissues using data from the genotype-tissue expression (GTEx) project.

Patients with subacute subdural hematoma (sASDH) do not have an optimal non-surgical therapeutic strategy. In this study, scientists from Capital Medical University, Beijing, and Tianjin Medical University, Tianjin, present five case studies where patients received atorvastatin plus low-dose dexamethasone for sASDH. They report resolution of hematomas in all patients, with no recurrence or progression during the six-month follow-up period.  This may be a potential alternative treatment for patients who prefer non-surgical therapy for sASDH.

T cells play a central role in the cancer immunity cycle. The therapeutic outcomes of T cell-based intervention strategies are determined by multiple factors at various stages of the cycle. This review summarizes and discusses recent advances in, and potential barriers to, T-cell immunotherapy, within the framework of the cancer immunity cycle, including T-cell recognition of tumor antigens for activation, T-cell trafficking and infiltration into tumors, and killing of target cells. Moreover, they discuss the key factors influencing T cell differentiation and functionality, including TCR stimulation, costimulatory signal, cytokines, metabolic reprogramming, and mechanistic forces. The authors also highlight the key transcription factors dictating T cell differentiation and discuss how metabolic circuits and specific metabolites shape the epigenetic program of tumor-infiltrating T cells. In conclusion, a better understanding of T cell fate decisions will help design new strategies to overcome barriers to effective immunization against cancer.

This study presents a chip-scale acousto-optic phase modulation approach based on flexible PDMS for generating sub-MHz interleaved frequency combs for higher-resolution. When integrated with plasmonic nanostructures, the system enables a next-generation platform for precision direct frequency comb spectroscopy.

As the world shifts toward sustainable transportation, electric vehicles (EVs) have emerged as a key solution to reducing greenhouse gas emissions. However, one major hurdle remains: efficient and convenient charging. While wireless power transfer (WPT) has gained traction, most systems rely on inductive charging, which requires bulky ferrite cores and suffers from misalignment issues.

As the world grapples with climate change, the shift toward sustainable transportation has become imperative. Electric vehicles (EVs) are at the forefront of this transition, offering cleaner and more efficient alternatives to fossil fuel-powered cars. However, the widespread adoption of EVs faces challenges, particularly in charging infrastructure. Wireless power transfer (WPT) technology presents a promising solution, eliminating the need for physical connectors and enabling seamless charging. Among WPT methods, inductive power transfer (IPT) stands out due to its reliability and efficiency. This study focuses on optimizing circular coils with ferrite cores to enhance IPT efficiency for EVs, addressing critical limitations such as misalignment tolerance and electromagnetic field (EMF) dispersion. 

The global transition to renewable energy faces a critical challenge: maintaining stable power grids as we integrate intermittent solar/wind generation and growing numbers of electric vehicles. This groundbreaking research presents an intelligent solution that could transform how we manage these complex energy systems.