Review outlines distinct patient subgroups to advance personalized treatment for heterogeneous heart failure
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Oct-2026 14:16 ET (25-Oct-2026 18:16 GMT/UTC)
Heart failure represents a highly diverse global syndrome, and classification relying only on left‑ventricular ejection fraction cannot fully explain variable treatment responses, especially among patients with heart failure with preserved ejection fraction (HFpEF). This peer‑reviewed narrative review synthesizes published human clinical evidence from major databases up to December 2024. Authors describe five distinct HFpEF clinical phenotypes defined by comorbid conditions: metabolic, hypertensive, cardiorenal, pulmonary vascular, and inflammatory‑autoimmune subtypes. Each phenotype carries unique pathophysiology that may support phenotype‑specific therapy. The review notes that robust head‑to‑head treatment trials for these subgroups remain limited, calling for further prospective research before widespread real‑world adoption of precision‑based heart‑failure management.
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