The article “Plasma oxylipin profiling by high resolution mass spectrometry reveals signatures of inflammation and hypermetabolism in amyotrophic lateral sclerosis” is at: www.sciencedirect.com/science/article/abs/pii/S0891584923005993.

Results of trials involving animals, cell cultures and human heart tissue are reported in the European Heart Journal. The study was conducted by researchers at USP in partnership with a biopharmaceutical firm, offering hope to 2 million Brazilians who suffer from the disease.

The test developed by Brazilian researchers accurately identifies the causative agent in less than two hours, so that treatment can be properly targeted. Brazil is seeing a growing number of cases of co-infection by protozoans Leishmania infantum and Crithidia.

Highlighted on the cover of the journal Biochemistry, a study by Brazilian researchers shows that a chemical change called pyroglutamination can occur spontaneously during peptide synthesis. The discovery has implications for laboratory experiments and research on Alzheimer’s, Parkinson’s and other diseases associated with the formation of amyloid aggregates.

A study compared geographical and socioeconomic dimensions of the disease in São Paulo and the Barretos region. Incidence was far higher in the former but mortality rates were similar, suggesting overdiagnosis in specific areas and social groups.