A Brazilian study made important progress in understanding the accumulation of one of the proteins involved in amyotrophic lateral sclerosis (ALS). Scientists were able to gain insight into the interaction between normal and mutant forms of a protein known as superoxide dismutase 1 (Sod1). The process alters protein accumulation in the cell, but also impairs the function of Sod1 protein, thus contributing to the development of the disease.