TripletDGC: Assessing critical cell types of disease genes by integrating single-cell genomics and human genetics
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Dec-2025 23:11 ET (23-Dec-2025 04:11 GMT/UTC)
TripletDGC links disease genes→cell types→diseases via eQTL-scRNA integration, exposing sparse but critical cell drivers and potential comorbidity
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A new study published in Microbiome Research Reports reveals that a polyphenol-rich dietary pattern can significantly reduce inflammation and improve gut microbiota composition in adults aged 60 years and older with elevated inflammatory markers. Conducted as part of the MaPLE (Microbiome mAnipulation through Polyphenols for managing Leakiness in the Elderly) trial, this research showed that an eight-week polyphenol-rich diet decreased key inflammatory markers such as IL-6 and CRP, enhanced microbial diversity, and increased beneficial bacteria including Blautia and Dorea. Metabolomic analyses indicated notable shifts in polyphenol-derived metabolites associated with anti-inflammatory effects. These findings highlight the potential of polyphenol-rich diets as personalized nutritional strategies to counteract “inflammaging” and promote healthy aging.