As environmental pollutants pose a serious threat to socioeconomic and environmental health, the development of simple, efficient, accurate and cost-effective methods for pollution monitoring and control remains a major challenge, but it is an unavoidable issue. In the past decade, the artificial nanozymes have been widely used for environmental pollutant monitoring and control, because of their low cost, high stability, easy mass production, etc. However, the conventional nanozyme technology faces significant challenges in terms of difficulty in regulating the exposed crystal surface, complex composition, low catalytic activity, etc. In contrast, the emerging single-atom nanozymes (SANs) have attracted much attention in the field of environmental monitoring and control, due to their multiple advantages of atomically dispersed active sites, high atom utilization efficiency, tunable coordination environment, etc. To date, the insufficient efforts have been made to comprehensively characterize the applications of SANs in the monitoring and control of environmental pollutants. Building on the recent advances in the field, this review systematically summarizes the main synthesis methods of SANs and highlights their advances in the monitoring and control of environmental pollutants. Finally, we critically evaluate the limitations and challenges of SANs, and provide the insights into their future prospects for the monitoring and control of environmental pollutants.

Manganese-based chalcogenides have significant potential as anodes for sodium-ion batteries (SIBs) due to their high theoretical specific capacity, abundant natural reserves, and environmental friendliness. However, their application is hindered by poor cycling stability, resulting from severe volume changes during cycling and slow reaction kinetics due to their complex crystal structure. Here, an efficient and straightforward strategy was employed to in-situ encapsulate single-phase porous nanocubic MnS_0.5Se_0.5 into carbon nanofibers using electrospinning and the hard template method, thus forming a necklace-like porous MnS_0.5Se_0.5-carbon nanofiber composite (MnS_0.5Se_0.5@N-CNF). The introduction of Se significantly impacts both the composition and microstructure of MnS_0.5Se_0.5, including lattice distortion that generates additional defects, optimization of chemical bonds, and a nano-spatially confined design. In situ/ex-situ characterization and density functional theory calculations verified that this MnS_0.5Se_0.5@N-CNF alleviates the volume expansion and facilitates the transfer of Na⁺/electron. As expected, MnS_0.5Se_0.5@N-CNF anode demonstrates excellent sodium storage performance, characterized by high initial Coulombic efficiency (90.8%), high-rate capability (370.5 mAh g^-1 at 10 A g^-1) and long durability (over 5000 cycles at 5 A g^-1). The MnS_0.5Se_0.5@N-CNF//NVP@C full cell, assembled with MnS_0.5Se_0.5@N-CNF as anode and Na₃V₂(PO₄)₃@C as cathode, exhibits a high energy density of 254 Wh kg^-1 can be provided. This work presents a novel strategy to optimize the design of anode materials through structural engineering and Se substitution, while also elucidating the underlying reaction mechanisms.

Researchers explore how 6-PPD quinone (6-PPDQ), an environmental contaminant derived from tire antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD), affects the citric acid cycle in C. elegans at environmentally relevant concentrations. The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ exposure, highlighting the its potential exposure risk on citric acid cycle metabolism.

The researchers developed a green and simple method to synthesize a silica aerogel that integrates two contrasting functional groups including methyl and amine. The aerogel not only has high adsorption capacity for low-concentration CO₂ but also possesses excellent thermal insulation performance under humid and high-temperature conditions.

Objectives: This systematic review aimed to assess the properties and feasibility of existing risk pre diction models for post-intensive care syndrome outcomes in adult survivors of critical illness. Methods: As of November 1, 2023, Cochrane Library, PubMed, Embase, CINAHL, Web of Science, PsycInfo, China National Knowledge Infrastructure (CNKI), SinoMed, Wanfang database, and China Science and Technology Journal Database (VIP) were searched. Following the literature screening process, we extracted data encompassing participant sources, post-intensive care syndrome (PICS) outcomes, sample sizes, missing data, predictive factors, model development methodologies, and metrics for model per formance and evaluation. We conducted a review and classification of the PICS domains and predictive factors identified in each study. The Prediction Model Risk of Bias Assessment Tool was employed to assess the quality and applicability of the studies. Results: This systematic review included a total of 16 studies, comprising two cognitive impairment studies, four psychological impairment studies, eight physiological impairment studies, and two studies on all three domains. The discriminative ability of prediction models measured by area under the receiver operating characteristic curve was 0.68e0.90. The predictive performance of most models was excellent, but most models were biased and overfitted. All predictive factors tend to encompass age, pre ICU functional impairment, in-ICU experiences, and early-onset new symptoms. Conclusions: This review identified 16 prediction models and the predictive factors for PICS. Nonetheless, due to the numerous methodological and reporting shortcomings identified in the studies under review, clinicians should exercise caution when interpreting the predictions made by these models. To avert the development of PICS, it is imperative for clinicians to closely monitor prognostic factors, including the in ICU experience and early-onset new symptoms.

Researchers from the Chinese Academy of Sciences and Capital Medical University performed an integrated multi-omics study to compare the effects of acute versus long-term exercise in healthy men. Acute exercise led to temporary responses, while repeated exercise caused adaptive changes, particularly reducing cellular senescence and inflammation and boosting betaine metabolism. The increase in betaine due to exercise, partly through renal biosynthesis, has anti-aging effects and improves age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), slowing the aging process. These results provide a comprehensive understanding of the molecular benefits of exercise and identify betaine as a potential exercise mimetic for promoting healthy aging.

This review explores the interplay between COVID-19 and malaria, with a focus on pregnant women. The concurrent infection of SARS-CoV-2 and malaria presents significant challenges in diagnosis, treatment, and management due to overlapping symptoms and complex immune responses. Genetic factors, particularly variations in the angiotensin-converting enzyme 2 (ACE2) receptor, play a crucial role in determining disease susceptibility and severity. Malaria-induced immunomodulation may influence the clinical progression of COVID-19, though the precise impact remains uncertain. The review emphasizes the need for integrated diagnostic and therapeutic approaches to effectively manage co-infections and improve maternal and fetal health outcomes. It underscores the importance of timely intervention and enhanced diagnostic methods to better understand and address these interactions. This review aims to bridge gaps in current knowledge and pave the way for future research and targeted therapeutic interventions, addressing a significant yet often overlooked public health challenge.

Chirality is one of the essential attributes of nature. Chiral drugs refer to a class of drugs containing chiral centers, and the molecular stereo-structures of their enantiomers are non-superimposable mirror images of each other. Sixty percent of commonly used drugs, including those from traditional Chinese medicine (TCM), are chiral. Developing a single enantiomer with high efficiency and low toxicity has drawn considerable attention due to significant differences in pharmacological activities, metabolic processes, and toxicity exhibited by the enantiomers of chiral drugs. This review concisely summarizes chiral drugs, including their sources, absolute configuration identification, pharmacological applications, and future research trends, particularly in TCM.

Since the early 20th century, viral infections such as SARS, dengue fever, AIDS, Ebola, influenza and herpes have been among the most common causes of illness and death worldwide. These viruses multiply quickly and lead to epidemics and pandemics. Unfortunately, no drug has been proven to be therapeutically effective in treating or preventing dengue fever. The focus of the review is on computational approaches such as molecular docking and simulation methods to evaluate the stability, inhibition mechanisms and binding interactions of rosmarinic acid (RA) against dengue virus proteins. Based on computational studies, it can be concluded that RA could hinder the spread of dengue virus due to its significant binding and docking affinities with its proteins. Due to its anti-inflammatory properties, broad-spectrum antiviral activity, and desirable low-toxicity pharmacokinetic profile, it is also a viable drug for further experimental validation. The review concludes by discussing how to interpret the in silico data, the shortcomings of the computational method, and the need for further experimental validation to fully explore the potential of RA as a treatment option for dengue.