A team of researchers has developed a new type of imaging sensor that uses both light and sound to create detailed pictures of biological tissues. This marks the first successful use of an array of over 40 microscopic, polymer-based "microrings" to capture these types of images. It can track oxygen levels, blood flow, and how dense blood vessels are. Therefore, it is much more effective at spotting the early signs of cancer.

Progesterone insensitive has long hindered fertility-preserving treatment for endometrial cancer. Now in Science Bulletin, researchers from Peking University People's Hospital and Peking University, in collaboration with Beihang University show that cholesteryl ester accumulation in the tumor microenvironment predicts response. Adding statins to standard therapy reverses progesterone insensitivity, significantly increasing the likelihood of both achieving endometrial cancer remission and preserving future fertility.

Recently, a research team led by Prof. LIU Xiaodi from the Hefei Institute of Solid State Physics, Hefei Institutes of Physical Science of the Chinese Academy of Sciences, in collaboration with the University of Edinburgh and other international partners, has provided new insight into this long-standing question by combining high-pressure experiments with first-principles calculations.

The process of embryo implantation is complex yet highly coordinated, involving differentiation of multiple cell types and dynamic mechanistic or compensatory shifts in metabolic patterns. Metabolic regulation plays a critical role in embryo implantation by modulating embryo competence and endometrial receptivity. Accordingly, metabolites function not only as sources of energy but also as signaling molecules that orchestrate communication between the endometrium and blastocyst. Here, we review the regulatory roles of key metabolites, including carbohydrates, lipids, amino acids, and their derivatives in various reproductive processes, such as blastocyst formation and activation, establishment of uterine receptivity, and embryo implantation. Interpretation of metabolic signaling may help to elucidate the intricate process of embryo implantation and provide new insights into potential clinical interventions and improvements in assisted reproductive technology.

This study aimed to determine the association of excessive gestational weight gain (GWG) and the glycated hemoglobin (HbA1c) level with adverse pregnancy outcomes in patients with gestational diabetes mellitus (GDM).

Researchers have developed a super-hydrated supramolecular hydrogel that combines high mechanical strength with persistent low friction. Inspired by natural articular cartilage, the material leverages zwitterionic units to form a stable hydration layer and microphase-separated structure, achieving a friction coefficient as low as 0.057 and maintaining lubrication over 100,000 sliding cycles.

Harnessing the power of generative AI, researchers at Tsinghua University have developed AIGP—a diffusion-based generative framework that enables instant translation of optical properties into fabrication-ready metasurfaces. By using transmission, phase, and polarization as “prompts,” AIGP directly maps optical properties to subwavelength, fabricable structures, generating high-fidelity metasurface designs in seconds. This breakthrough overcomes critical bottlenecks in photonic inverse design and paves the way for large-scale, AI-driven generative optical devices.

A 72-year-old man developed aggressive skin cancer on his left thumb 30 years after a burn injury, illustrating the decades-long latency of Marjolin ulcer. This rare but deadly cancer behaves far more aggressively than common skin cancers, underscoring the critical need for lifelong monitoring of old scars and immediate biopsy of any suspicious changes.