Parkinson’s disease (PD) is a complex genetic neurodegenerative disorder. Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology, especially when associated with the advent of genome-wide association studies (GWAS) technologies in the discovery of the risk linked to common germline genetic variants. The biggest limitation of those studies on genetic susceptibility to PD is the lack of information describing the impact of individuals’ ancestry on risk associations, especially in non-European populations. Current genetic data are mainly based on individuals of European origin, particularly those included in the UK biobank project. The effects of these ethical discrepancies can directly impact the discovery of risk variants associated with PD susceptibility and clinical management of PD patients in admixture populations, for example. Thus, we performed a PROSPERO-registered systematic review to elucidate the current state of the art about the role of common genetic variants based on GWAS studies in advancing precision medicine for PD susceptibility and pathobiology in multiethnic and non-European populations. Also, we discuss whether there are similarities or discrepancies of these data in relation to genomic data obtained in studies with PD patients of European origin.

Quasi-solid-state composite electrolytes (QSCEs) show promise for high-performance solid-state batteries, while they still struggle with interfacial stability and cycling performance. Herein, a F-grafted QSCE (F-QSCE) was developed via copolymerizing the F monomers and ionic liquid monomers. The F-QSCE demonstrates better overall performance, such as high ionic conductivity of 1.21 mS cm^–1 at 25 °C, wide electrochemical windows of 5.20 V, and stable cycling stability for Li//Li symmetric cells over 4000 h. This is attributed to the significant electronegativity difference between C and F in the fluorinated chain (‒CF₂‒CF‒CF₃), which causes the electron cloud to shift toward the F atom, surrounding it with a negative charge and producing the inductive effect. Furthermore, the interactions between Li⁺ and F, TFSI^‒, and C are enhanced, reducing ion pair aggregation (Li⁺‒TFSI^‒‒Li⁺) and promoting Li⁺ transport. Besides, ‒CF₂‒CF‒CF₃ decomposes to form LiF preferentially over TFSI^–, resulting in better interfacial stability for F-QSCE. This work provides a pathway to enable the development of high-performance Li metal batteries.

A research team has uncovered how ethylene, a key plant hormone, enhances peanut seed germination by modulating hormonal pathways and promoting metabolic processes.

New research helps narrow down uncertainties in near-term precipitation projections for the Asian Water Tower