News from China
Updates every hour. Last Updated: 28-Oct-2025 14:11 ET (28-Oct-2025 18:11 GMT/UTC)
How a prehistoric genetic split helped plants conquer polluted soils
Nanjing Agricultural University The Academy of ScienceAn ancient genetic event may hold the key to how plants survive in metal-contaminated environments. Scientists have discovered that a duplication of phytochelatin synthase (PCS) genes—crucial enzymes for detoxifying toxic metals—occurred millions of years ago and remains conserved in flowering plants today. These twin gene copies, known as D1 and D2, evolved distinct but complementary functions: while D1 plays a general role in detoxification, D2 exhibits exceptional catalytic activity against cadmium and arsenic. Functional tests in Malus domestica (MdPCS1, MdPCS2) and Medicago truncatula (MtPCS1, MtPCS2) revealed that both copies are indispensable for maintaining metal balance, unveiling a deep evolutionary strategy for resilience.
- Journal
- Horticulture Research
Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
Chinese Medical Journals Publishing House Co., Ltd.This review focuses on how immunosenescence and inflammaging impact immune checkpoint inhibitor (ICI) efficacy and safety in older cancer patients.
Immunosenescence impairs T/NK cell function (e.g., reduced TCR diversity, CD28⁻CD57⁺ senescent T cells) and expands immunosuppressive cells (Tregs, MDSCs). Inflammaging causes inflammatory imbalance via SASP and DAMPs. Both reduce ICI efficacy and increase immune-related adverse events (irAEs).
Its innovation lies in systematically linking these age-related factors to ICI outcomes. Clinically, it suggests using SIP⁺ T cell ratio/cytokine levels to predict efficacy, and proposes a scoring system to optimize elderly patients' ICI therapy.
- Journal
- Cancer Pathogenesis and Therapy
Co-culture models for investigating cellular crosstalk in the glioma microenvironment
Chinese Medical Journals Publishing House Co., Ltd.This review summarizes 2D (direct/indirect contact, e.g., Transwell) and 3D (cell/tissue/organoid-based, microfluidic, 3D-bioprinted) co-culture models for studying glioma-tumor microenvironment (TME) cell crosstalk (glioma with endothelial cells, neurons, immune cells, etc.).
Its innovation lies in systematically integrating diverse models and emphasizing understudied multi-cell interactions. Clinically, these models enable mechanistic research and drug screening, providing insights for developing TME-targeted therapies to improve glioma treatment efficacy.
- Journal
- Cancer Pathogenesis and Therapy
Global analysis reveals how biochar supercharges composting and cuts greenhouse gases
Biochar Editorial Office, Shenyang Agricultural UniversityPeer-Reviewed Publication
Biochar and iron additives show promise for reviving degraded peatlands and locking away carbon
Biochar Editorial Office, Shenyang Agricultural UniversityPeer-Reviewed Publication
- Journal
- Biochar
Charting the future of carbon fiber composite recycling
Biochar Editorial Office, Shenyang Agricultural University- Journal
- Carbon Research
Steric hindrance controls supramolecular dissociation kinetics and material properties
Chinese Chemical SocietyPeer-Reviewed Publication
A team led by Associate Researcher Zhaoming Zhang and Researcher Xuzhou Yan from Shanghai Jiao Tong University introduced pseudorotaxane end groups of varying sizes and utilized their steric hindrance to modulate the dissociation kinetics of supramolecular crosslinks, thereby achieving control over the mechanical properties of supramolecular polymer networks (SPNs). This study systematically elucidated the relationship between supramolecular structure, dissociation kinetics, and macroscopic mechanical properties of the network, providing new insights into the development of high-performance SPNs.
- Journal
- CCS Chemistry
USTC scientists uncover mystery of neurotransmission with time-resolved cryo-ET
University of Science and Technology of ChinaPeer-Reviewed Publication
A research team led by Prof. BI Guo-Qiang from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), in collaboration with several domestic and international institutions, has resolved a 50-year-old controversy in neuroscience. By employing a self-developed, time-resolved cryo-electron tomography (cryo-ET) technique, the team has delineated the intricate choreography of synaptic vesicle (SV) release and rapid recycling, the cornerstone of neural communication. Their findings, which introduce a new biophysical mechanism termed the “Kiss-Shrink-Run”, were published in Science on October 17 (Beijing time).
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- Science
How a tiny zinc finger protein determines tomato fruit size
Nanjing Agricultural University The Academy of ScienceThe secret to tomato size lies within the flower's core. Scientists have discovered that the gene SlKNUCKLES (SlKNU), which encodes a zinc finger protein, serves as a key switch that determines fruit size by regulating floral meristem activity—the tissue responsible for forming reproductive organs.
- Journal
- Horticulture Research