Winter arrives with shorter days, colder mornings, and a natural drop in energy. Many men start to feel small physical changes during this season, such as slower digestion, disrupted bowel habits, or a weaker urine stream. These winter symptoms should not be neglected, as some of them are on the checklist of potential cancer symptoms. Advanced genetic testing is reshaping precision oncology, not only for early screening but also for precision treatment. High-throughput sequencing technology-based cancer discovery testing is now helping doctors understand the personal genetic drivers of disease and provide guidance for the most effective treatment solutions, leading to better outcomes.

Researchers at Beijing Tiantan Hospital analyzed 101 glioma cases involving the brain’s motor pathway and found that one-third of patients developed permanent paralysis after surgery. High tumor grade, pre-operative motor deficits, and larger tumor volume were key predictors. The work underscores the need for precise imaging and careful surgical planning to maximize survival while safeguarding motor function.

Alzheimer’s disease (AD) imposes a substantial clinical and societal burden, yet currently approved symptomatic therapies do not modify the underlying disease biology. Recently, three anti-amyloid monoclonal antibodies (aducanumab, lecanemab, and donanemab) have demonstrated robust amyloid clearance. Their clinical effects are statistically significant but modest, underscoring the need for broader, biologically informed strategies. Guided by the 2024 Alzheimer’s association ATNIVS biomarker framework, a team form Xuanwu Hospital, Capital Medical University synthesizes disease-modifying therapies (DMTs) targeting amyloid (A), tau (T), neurodegeneration (N), inflammation (I), vascular injury (V), and α-synuclein (S), summarizing the candidate therapies for each target, explain the mechanisms of action and pivotal clinical trial results. The review is currently published on the journal Medicine Plus.

Researchers report a molecular design strategy for high-voltage organic cathodes in aluminum batteries. By constructing a sulfur-heterocyclic polymer with weak electron-donating effect and super-crosslinked sites, the cathode achieves a high voltage of ~1.7 V and a high capacity of 150 mAh g⁻¹. The designed organic cathode achieves a record 255 Wh kg⁻¹ energy density, breaking the upper limit of conventional graphite cathodes (~200 Wh kg⁻¹).

While unitized regenerative fuel cells (URFCs) are promising for renewable energy storage, their efficient operation requires simultaneous water management and gas transport, which is challenging from the standpoint of water management. Herein, a novel approach is introduced for examining the alignment hydrophilic pattern of a Ti porous transport layer (PTL) with the flow field of a bipolar plate (BP). UV/ozone patterning and is employed to impart amphiphilic characteristics to the hydrophobic silanized Ti PTL, enabling low-cost and scalable fabrication. The hydrophilic pattern and its alignment with the BP are comprehensively analyzed using electrochemical methods and computational simulations. Notably, the serpentine-patterned (SP) Ti PTL, wherein the hydrophilic channel is directly aligned with the serpentine flow field of the BP, effectively enhances oxygen removal in the water electrolyzer (WE) mode and mitigates water flooding in the fuel cell (FC) mode, ensuring uninterrupted water and gas flow. Further, URFCs with SP configuration exhibit remarkable performance in the WE and FC modes, achieving a significantly improved round-trip efficiency of 25.7% at 2 A cm⁻².

Weyl semimetals, hosting chiral Weyl fermions with momentum-locked spin textures, offer a promising platform for developing quantum information technologies based on chiral degrees of freedom. Recently, Professor Dong Sun’s group at Peking University demonstrated selective injection of chiral Weyl fermions in the magnetic Weyl semimetal Co₃Sn₂S₂ using circularly polarized mid-infrared light through a third-order nonlinear optical process under a static electric field. By tuning both the external electric field and the ferromagnetic order, they achieved flexible and reversible control of chiral optical responses. Helicity-dependent photocurrent measurements revealed strong mid-infrared chiral signals, including wavelength-dependent sign reversals associated with imbalanced excitation of oppositely polarized Weyl fermions, confirming their Weyl-cone origin. This work highlights the exceptional tunability of magnetic Weyl semimetals for chiral regulation and establishes a foundation for future quantum devices based on chiral information carriers. The study was published in National Science Review (2025), with the School of Physics at Peking University as the first affiliation; Zipu Fan is the first author, and Professors Dong Sun, Jinluo Cheng, and Enke Liu are the corresponding authors.

To ensure the safe and stable operation of superconducting magnets in fusion devices under high current and complex operating conditions, a highly reliable quench detection system was developed for the Central Solenoid Model Coil (CSMC) of the Chinese Fusion Engineering Testing Reactor (CFETR). The system adopts voltage-based detection as the primary criterion and implements a primary induced voltage compensation architecture based on Co-Wound Wire (CWW) and Co-Wound Tape (CWT) techniques. In addition, a secondary compensation algorithm is introduced to effectively suppress the risk of misjudgment caused by electromagnetic coupling. In the system design, a multi-redundant compensation scheme was proposed with full consideration of the magnet structure and cabling constraints. During the engineering commissioning phase, both room-temperature continuity tests and low-current compensation coefficient calibration were conducted. Induced voltage suppression tests under different current variation rates demonstrated that CWT provides superior compensation performance compared to CWW, with induced voltage suppression rates exceeding 99.8 % for CWW and 99.95 % for CWT. Furthermore, reliability tests under three simulated fault scenarios confirmed that the diagnostic system could accurately identify system states without false triggers, showing strong anti-interference capability and engineering stability. Ultimately, the system was successfully deployed in a high-current energization test of the CSMC, operating at up to 48 kA. It maintained stable performance throughout the test without any false alarms or missed detections, verifying its feasibility and reliability under real engineering conditions. The quench detection compensation methods and system architecture proposed in this study provide a solid technical foundation and practical support for the future development and deployment of the CFETR Central Solenoid superconducting magnet quench detection system.

 Optical Frequency Domain Reflectometry (OFDR), based on Rayleigh scattering, offers an innovative diagnostic approach for superconducting magnets. In addition to its high spatial resolution, electromagnetic immunity, and distributed sensing capability, OFDR allows continuous and quantitative mapping of thermomechanical states throughout the magnet's lifecycle -- from initial winding pre-stress and cooldown to excitation and quench. For critical performance monitoring, particularly in tracking the combined strain-temperature behavior under cryogenic and high-field conditions, OFDR provides a level of accuracy and spatial detail that is difficult to match with existing sensing methods. Although engineering challenges remain, including cryogenic calibration, strain transfer, signal decoupling, and system integration, most can be resolved as the technology matures. Looking ahead, OFDR is poised to become a core technology for next-generation “smart” superconducting structures, redefining diagnostic strategies in high-energy physics and fusion magnet systems.

A nonfused ring electron acceptor (NFREA), designated as TT-Ph-C6, has been synthesized with the aim of enhancing the power conversion efficiency (PCE) of organic solar cells (OSCs). By integrating asymmetric phenylalkylamino side groups, TT-Ph-C6 demonstrates excellent solubility and its crystal structure exhibits compact packing structures with a three-dimensional molecular stacking network. These structural attributes markedly promote exciton diffusion and charge carrier mobility, particularly advantageous for the fabrication of thick-film devices. TT-Ph-C6-based devices have attained a PCE of 18.01% at a film thickness of 100 nm, and even at a film thickness of 300 nm, the PCE remains at 14.64%, surpassing that of devices based on 2BTh-2F. These remarkable properties position TT-Ph-C6 as a highly promising NFREA material for boosting the efficiency of OSCs.