Innovative regenerative therapies restore uterine function in fibrotic endometrial disorders
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Jul-2025 22:11 ET (24-Jul-2025 02:11 GMT/UTC)
Groundbreaking research reveals the potential of stem cell-based therapies combined with biomaterials in effectively treating intrauterine adhesions (IUA) and thin endometrium (TE), two common causes of infertility.
Deep-penetration light-triggered pyroptosis based on nanomedicine for tumor precision therapy still remains challenging. Towards this goal, Scientist in China reported a supramolecular engineering strategy to construct Pt(IV)-coordinated supra-(carbon dots) with NIR-activated photocatalytic capacity to trigger tumor pyroptosis, thereby evoking anti-tumor immune responses to suppress distant tumor and prevent cancer metastasis. The finding will open new avenues for precision phototherapy in future clinical oncology by supramolecular-mediated nanomedicine with deep-penetration light triggered pyroptosis.
Researchers from Institute of Physics, Chinese Academy of Sciences, have developed an new strategy for designing highly efficient and cost-effective catalysts for electrochemical water splitting, a crucial process in the production of green hydrogen. The new catalyst based on nanoporous metallic glass exhibits remarkable electrocatalytic performance, requiring only 1.53 V bias to achieve a current density of 10 mA cm⁻² for overall water-splitting. This surpasses the current performance of commercial Pt/C || IrO2 catalysts, which require 1.62 V.
Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination of C5a and C5aR1 in macrophages induces M2 polarization. There is no consistent conclusion regarding macrophage polarization status and its participation in the pathogenesis of endometriosis.
In a perspective piece published in MedComm, Dr. Thakor introduces the innovative concept of Precision Delivery, aimed at maximizing the effectiveness of Precision Medicine in providing personalized healthcare. This new pillar will complement the established components of Precision Medicine — Precision Diagnosis and Precision Therapy — by serving as a crucial third pillar to enhance the successful clinical translation of existing and new emerging therapies into patients.
Researchers from Peking University and collaborators have proposed a novel scheme to realize quantum controlled-Z (CZ) gates using a single gradient metasurface. This innovation enables high-density and multifunctional quantum integration on a chip, paving the way for efficient on-chip quantum information processing.