Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Jul-2025 10:11 ET (25-Jul-2025 14:11 GMT/UTC)
Senescence, aging, and age-related diseases represent complex biological phenomena with significant impacts on human health, and metabolism and metabolomics play pivotal roles in understanding their mechanisms and interventions. This comprehensive review integrates multiscale perspectives to elaborate on the intricate relationships among metabolism, cellular senescence, organismal aging, and diseases such as cardiovascular disorders, neurodegenerative diseases, diabetes, and osteoporosis.
ARMC5, a cytoplasmic protein encoded by a gene rich in armadillo (ARM) repeat sequences, has emerged as a critical regulator of cellular processes, with implications spanning tumor suppression, endocrine disorders, and immune modulation. Ubiquitously expressed across human tissues, ARMC5 lacks enzymatic activity but mediates protein-protein interactions through its ARM repeats and BTB/POZ domain. These structural features enable it to act as a scaffold for ubiquitin ligase complexes, influencing protein degradation via the ubiquitin-proteasome system (UPS). Initially identified as a tumor suppressor linked to bilateral macronodular adrenocortical disease (BMAD), ARMC5’s role has expanded to include associations with meningiomas, primary aldosteronism (PA), renal cell carcinoma (RCC), and embryonic development.
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