The global antibiotic resistance crisis necessitates alternatives like bacteriophage therapy. However, bacterial phage resistance remains challenging. The authors developed a phage cocktail targeting carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) that exploits the dual-layered collateral sensitivity to suppress resistance evolution. The first layer leveraged overlapping capsular polysaccharide (CPS) and lipopolysaccharide (LPS) coverage: CPS-binding phage resistance increased susceptibility to LPS-binding phages. The second layer exploited an O serotype switch (O1→O2): resistance to O1-binding phages increased susceptibility to O2-binding phages. This dual-mechanism cocktail effectively constrained phage resistance development and mitigated CR-hvKp infection in mice. This research highlights collateral sensitivity's importance in countering phage resistance and provides a sophisticated phage cocktail design strategy to overcome bacterial resistance.

In an era of growing demand for real-time precision navigation, researchers have unveiled a powerful leap forward in satellite-based positioning. 

Fluoropolymers promise all-solid-state lithium metal batteries (ASLMBs) but suffer from two critical challenges. The first is the trade-off between ionic conductivity (σ) and lithium anode reactions, closely related to high-content residual solvents. The second, usually consciously overlooked, is the fluoropolymer’s inherent instability against alkaline lithium anodes. Here, we propose indium-based metal–organic frameworks (In-MOFs) as a multifunctional promoter to simultaneously address these two challenges, using poly(vinylidene fluoride–hexafluoropropylene) (PVH) as the typical fluoropolymer. In-MOF plays a trio: (1) adsorbing and converting free residual solvents into bonded states to prevent their side reactions with lithium anodes while retaining their advantages on Li⁺ transport; (2) forming inorganic-rich solid electrolyte interphase layers to prevent PVH from reacting with lithium anodes and promote uniform lithium deposition without dendrite growth; (3) reducing PVH crystallinity and promoting Li-salt dissociation. Therefore, the resulting PVH/In-MOF (PVH-IM) showcases excellent electrochemical stability against lithium anodes, delivering a 5550 h cycling at 0.2 mA cm⁻² with a remarkable cumulative lithium deposition capacity of 1110 mAh cm⁻². It also exhibits an ultrahigh σ of 1.23 × 10⁻³ S cm⁻¹ at 25 °C. Moreover, all-solid-state LiFePO₄|PVH-IM|Li full cells show outstanding rate capability and cyclability (80.0% capacity retention after 280 cycles at 0.5C), demonstrating high potential for practical ASLMBs.

Inflammation is a natural immune response, but when uncontrolled, it can worsen many diseases. Recent studies show that metabolism plays a surprising role in regulating this response. A new editorial in the Journal of Intensive Medicine highlights findings on the glyoxalase system, a metabolic pathway that helps immune cells tone down inflammation. This insight opens new possibilities for treating inflammatory diseases through metabolic targets, offering a promising direction beyond traditional immunosuppressants.

In a recent breakthrough published in Optics & Laser Technology and Infrared Physics & Technology, a research team led by Prof. CHENG Tingqing at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences have introduced a novel low-thermal-effect gradient-doped crystal to tame thermal effects and improve brightness of high-power end-pumped Nd:YAG lasers.