Unveiling breast cancer’s metabolic landscape: A new perspective on targeted therapies
Peer-Reviewed Publication
This month, we're turning our attention to Breast Cancer Awareness Month, a time dedicated to increasing awareness, supporting early detection, and highlighting the ongoing research shaping the future of breast cancer treatment and prevention.
Updates every hour. Last Updated: 11-Oct-2025 18:11 ET (11-Oct-2025 22:11 GMT/UTC)
Breast cancer remains the most prevalent malignancy among women worldwide, posing a critical challenge to global health. Amid the complexities of this disease, an emerging focus on metabolic reprogramming has shed light on novel treatment avenues. A newly published review delves into the intricate alterations in glucose, lipid, and amino acid metabolism that drive breast cancer progression and explores promising therapeutic strategies designed to exploit these metabolic dependencies.
As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it. In a study of 591 women with early stage breast cancer who completed five years of endocrine therapy, 47% decided to continue the treatment.
Recent results from the NRG-NSABP B-51/RTOG 1304 clinical study showed that the addition of regional nodal irradiation (RNI) does not decrease the rates of invasive breast cancer recurrence in patients whose positive axillary nodes at presentation convert to negative following neoadjuvant chemotherapy. These results were recently published in the New England Journal of Medicine.