Ferrocene conjugated glutathione consumption for enhanced ferroptosis therapy and chemotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Jul-2025 17:11 ET (18-Jul-2025 21:11 GMT/UTC)
Research has shown that ferroptosis can overcome chemotherapy resistance induced by apoptosis, making the combination of chemotherapy and ferroptosis a very promising strategy for cancer treatment. However, the high levels of glutathione in the tumor environment and insufficient intracellular iron content limit the anticancer effects mediated by ferroptosis. Recently, a study published in Nano Research utilized the tumor environment to achieve a "multi-machine integrated" combined strategy, enhancing the therapeutic effects of chemotherapy and ferroptosis. The study was published in Nano Research with the DOI of 10.26599/NR.2025.94907298.
A research paper by scientists at Beijing Institute of Technology proposed an amplification-free electrochemiluminescence (ECL) biosensor using the CRISPR/Cas system for ultrasensitive detection of the specific gene fadA from F. nucleatum at femtomolar levels.
The new research paper, published on May. 1 in the journal Cyborg and Bionic Systems, provide the CRISPR/Cas12a system for the selective detection of fadA, a specific gene in F. nucleatum, followed by the verification of fluorescence and ECL analysis.
The Ag nanoparticles were deposited on the hBN surface, and the synergistic effect of hexagonal boron nitride nanosheets and silver nanoparticles was utilized to achieve superlubricity with very low coefficient of friction and wear rate.
A research paper just published in Science China Life Sciences reports that claudin-11 plays an important role in influenza virus endocytosis by disrupting the interaction between the endocytic receptor metabotropic glutamate receptor subtype 2 and potassium calcium-activated channel subfamily M alpha 1, and by disassembling the polymerized F-actin to facilitate influenza virus-containing clathrin-coated pit maturation.
In a paper published in SCIENCE CHINA Earth Sciences, an international team of researchers present the new details about the enhancement of aragonite precipitation during photosynthesis in Skeletonema costatum in artificial and natural seawater. By directly measuring cell surfaces, it reveals the mechanism of diatom-mediated promotion of CaCO3 precipitation. Based on this mechanism, it suggests that diatom-mediated calcification can occur in the oceans, which is supported by relevant phenomena. The newly found calcification pathway connects particulate inorganic and organic carbon flux, facilitating the reassessment of marine carbon export fluxes and CO2 sequestration efficiency. And this discovery may have significant implications for evaluating marine carbon cycling and predicting the impacts of future ocean acidification.