Researchers have developed an injectable supramolecular carrier that co‑encapsulates two hydrophobic anti‑inflammatory drugs within a hyaluronic acid matrix via Schiff‑base chemistry. The system achieves pH‑responsive release, suppresses inflammatory cytokines, promotes cartilage repair in a rat osteoarthritis model, and avoids the systemic toxicity of oral medications.

In vivo immune cell engineering directly reprograms endogenous immune cells, bypassing individualized ex vivo manufacturing and opening a path toward more accessible and scalable cell therapies. This review summarizes cell-specific engineering strategies, compares viral and non-viral delivery platforms, highlights emerging applications in cancer, autoimmune and degenerative diseases, and discusses the key challenges that must be overcome for clinical translation.

Researchers have developed an injectable supramolecular carrier that co‑encapsulates two hydrophobic anti‑inflammatory drugs within a hyaluronic acid matrix via Schiff‑base chemistry. The system achieves pH‑responsive release, suppresses inflammatory cytokines, promotes cartilage repair in a rat osteoarthritis model, and avoids the systemic toxicity of oral medications.

In vivo immune cell engineering directly reprograms endogenous immune cells, bypassing individualized ex vivo manufacturing and opening a path toward more accessible and scalable cell therapies. This review summarizes cell-specific engineering strategies, compares viral and non-viral delivery platforms, highlights emerging applications in cancer, autoimmune and degenerative diseases, and discusses the key challenges that must be overcome for clinical translation.

A new study reveals how microbial communities dynamically reorganize their metabolic functions during Shanxi aged vinegar fermentation. By integrating metatranscriptomic analysis with global metabolic profiling, researchers uncovered a stage-dependent metabolic transition from microbial growth and substrate utilization to acidification and stress adaptation. The study further identified a self-organizing microbial network characterized by functional division of labor and metabolic cooperation between key microorganisms, providing new insights into how traditional fermentation ecosystems achieve stability and develop unique flavor characteristics.

This work presents the first demonstration of a parallel heterodyne light-induced thermoelastic spectroscopy (PH-LITES) sensor for high-speed and high-sensitivity simultaneous multi-gas detection. By synergistically combining signal enhancement at the physical layer with intelligent decoupling at the information layer, the sensor achieves ppb-level simultaneous and fast multi-gas detection based on a single quartz tuning fork (QTF), providing an important reference for the future development of rapid and highly sensitive multi-gas sensing technologies.