Tendinopathy is a common and complex musculoskeletal disorder, unfortunately current clinical strategies for tendinopathy have low therapeutic efficacy because of complicated pathogenesis. Oxidative stress is considered as the major cause of tendinopathy as well as the important target, but still lacking ideal antioxidant solution. To this end , an efficient reactive oxygen species (ROS) biocatalyst, PtIrRuRhCu high-entropy alloy nanozyme (HEANZ), has been designed for treatment of tendinopathy. The non-ionic block copolymer (polyvinyl pyrrolidone) coated PtIrRuRhCu HEANZ with size of ~4.0 nm exhibit good biocompatibility and multiple enzyme-like antioxidant activity (including peroxidase, catalase and SOD-like) to modulate ROS. The therapeutic efficacy of PtIrRuRhCu HEANZ in tendinopathy has been systematically demonstrated in vitro and in vivo.  PtIrRuRhCu HEANZ can alleviate the TBHP(t-Butyl Hydroperoxide) stimulated tendinopathy by clearing ROS, reducing inflammation and restoring mitochondrial autophagy. Using PGAM5 siRNA and FUNDC1 siRNA for intervention, we clearly revealed that PtIrRuRhCu HEANZ promoted mitochondrial autophagy through upregulating the PGAM5/FUNDC1/GPX4 axis. This study provides a nanozyme strategy for the antioxidant treatment of tendinopathy and provides insights into the therapeutic mechanism. 

Color change during fruit ripening greatly influences visual appeal and market value. In apples, the transition from green to red or yellow depends on chlorophyll breakdown, yet the molecular link between hormonal and light cues has remained elusive. 

Transition metal dichalcogenides (TMDCs) is a two-dimensional (2D) layered material composed of transition metal elements and chalcogenide elements. Among them, supertwisted WS₂ spiral structure have attracted significant attention. As a twisted 2D layered material, supertwisted spirals exhibit multiple layers of continuous twisted structures, which give rise to their unique optoelectronic properties. Thus, the research of supertwisted spirals is very important.

As an additive manufacturing technique enabling complex geometric fabrication, direct ink writing (DIW) has established itself as a cornerstone technology for flexible electronics production. However, the inherent filament deposition process introduces anisotropic texture surface morphologies. Systematic investigation into the causal relationship between these topographical features and device performance is imperative for advancing performance-optimized flexible sensor architectures.

Transfer hydrogenation (TH) emerges as a frontier in hydrogenation science for utilizing safe and available non-H₂ hydrogen sources. Single-atom catalysts (SACs), with maximal atom utilization, well-defined active sites, and tunable structures, are attractive heterogeneous catalysts for TH due to the superior performance, clear structure-performance relationship, and low cost. This review categorizes TH by hydrogen sources, exploring the correlation between SACs’ structural characters and catalytic behaviors as well as corresponding synthetic strategies toward the featured structures of SACs. It also discusses challenges/opportunities remained in the field of TH promoted by SACs, guiding the design of high-performance SACs for the environmental-friendly and cost-effective hydrogenation technology.

Regarded as a superposition of the Kagome and the honeycomb lattice, the Kagome-honeycomb lattice potentially inherits the exotic electronic band structures of both sublattices, such as topologically nontrivial flat bands and linearly dispersing bands. Due to these unique band structures, the Kagome-honeycomb lattice may serve as a versatile platform for exploring various exotic physical phenomena, including the quantum anomalous Hall effect, tunable superconductivity, and (anti-)ferromagnetism. However, current research on Kagome-honeycomb lattices remains limited, only a few studies have constructed such lattices through hydrogen bonding or π-π interactions. Achieving large-area and well-ordered Kagome-honeycomb lattices remains a significant challenge.

The accurate and efficient detection of biomarker such as dopamine (DA) and alpha-fetoprotein (AFP) is crucial for clinical diagnosis, while the demand for materials with concurrent antibacterial activity remains urgent in medical and biological fields. In this study, a novel multifunctional PW₁₂@ZIF-67-Au (PZA) nanoreactor was successfully synthesized. This nanoreactor not only enables sensitive and reliable multivariate sensing of DA (a key neurotransmitter associated with neurological diseases) and AFP (a vital tumor marker for hepatocellular carcinoma), but also exhibits excellent antibacterial performance against common pathogenic bacteria like Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The research provides a promising integrated solution for biomolecular detection and antibacterial protection, laying a solid foundation for its potential applications in clinical diagnostic and related fields.

A new study in eGastroenterology links gut dysbiosis with severe steatosis in metabolic dysfunction–associated steatotic liver disease (MASLD). In a 61-patient cohort, those with the inflammation-linked Bact2 enterotype developed severe steatosis at lower thresholds. Adding microbiota status to standard clinical tools improved diagnostic accuracy from 80% to 90%, suggesting a path toward earlier detection and personalized care.

The international scientific and technological journal FlexTech, co-launched by Tsinghua University Press and Wiley, officially released its 2025 Issue 2.

Researchers demonstrated highly dispersed NaVO₃ nanoparticles, as a ^•CH₂Cl radical surface-confined coupling center, demonstrating its superior performance in the selective coupling of methyl chloride to synthesize vinyl chloride. By incorporating NaVO₃ onto the surface of CeO₂, the catalyst enables effective capture of ^•CH₂Cl radicals during the CH₃Cl oxidative pyrolysis and its subsequent conversion into C₂H₃Cl, achieving a C₂H₃Cl selectivity of 56.7% and a CH₃Cl conversion of 56.6% at 750 °C.