Agricultural azoles drive clinical azole resistance in Candida tropicalis via inducing aneuploidy
Peer-Reviewed Publication
Updates every hour. Last Updated: 27-Oct-2026 09:16 ET (27-Oct-2026 13:16 GMT/UTC)
In a paper published in Mycology, a team of scientists demonstrated that agricultural azole fungicides can induce broad-spectrum cross-resistance to first-line clinical azole antifungal drugs in Candida tropicalis, and elucidated that the core mechanism underlying this resistance is azole stress-driven formation of chromosomal aneuploidy coupled with the marked upregulation of associated azole resistance genes.
This article draws on eight recent studies published in Energy and Climate Management to assess the current status and future trajectory of China’s carbon market. While the national ETS has made notable progress, it remains constrained by low liquidity, weak price signals, and challenges in sectoral expansion—particularly due to MRV limitations. The studies highlight that improving institutional design, especially through robust price stabilization mechanisms, and introducing financial tools such as carbon futures are critical to enhancing market effectiveness. Insights from Japan and South Korea further underscore the importance of broader participation and policy flexibility. Overall, China’s carbon market is transitioning from institutional setup to market deepening, with growing emphasis on market-driven signals.
Researchers from Dalian University of Technology have developed an innovative seismic protection system that combines segmented rocking trusses with multiple tuned mass dampers (MTMD) to significantly improve the earthquake resilience of high-rise steel buildings. The proposed system overcomes the limitations of conventional rocking structures that are primarily effective only for first-mode vibration control. By dividing the rocking truss into multiple segments along the building height and strategically placing MTMDs based on the structure's vibration characteristics, the new design achieves uniform deformation distribution, prevents weak-story failure mechanisms, and reduces maximum inter-story drift ratios by 7% to 29%. The findings, published in Lifeline Emergency and Safety, demonstrate that this hybrid approach effectively controls multi-order vibration mode damage while maintaining the self-centering advantages of traditional rocking systems.
The growing threat of antimicrobial resistance (AMR) calls for effective solutions such as phage therapy. In China, phage therapy has been implemented in over 30 hospitals, treating more than 500 patients with multidrug-resistant infections. Phage therapy can currently be developed through two pathways: as a novel biomedical technology or as a new drug. However, regulatory ambiguity persists due to a lack of standardized quality criteria and clear approval frameworks. This article proposes a "standards first, pathway pilots, and industry cultivation" strategy. Key recommendations include developing national quality control guidelines for therapeutic phage preparations and clarifying the detailed guidelines for approval policies for new biomedical technologies, biologics, and advanced therapy medicinal products (ATMPs). These efforts aim to enable safe and effective clinical translation, positioning China as a frontrunner in phage therapy and making significant contributions to the global response against AMR.
High-resolution X-ray imaging is essential for medical diagnostics, security screening, and industrial non-destructive testing. However, conventional powder-polymer composite scintillator films usually require large thicknesses to ensure sufficient X-ray attenuation and brightness, while particle aggregation and interfacial heterogeneity inevitably cause severe light scattering and reduce imaging resolution. To address this challenge, a research team developed two optically homogeneous hybrid metal halide glasses, MTP2SbCl5 and MTP2MnCl4, through a scalable low-temperature melt-quenching strategy. These transparent glass scintillators exhibit visible–near-infrared transmittance up to ~90%, near-complete X-ray attenuation at 1 mm thickness, light yields of 5819 and 19232 photons MeV⁻¹, and high spatial resolutions of 18.8 and 22.5 lp mm⁻¹, respectively. Beyond imaging, the glasses also show excellent irradiation stability, reversible glass–crystal–glass transition, low-temperature self-healing, and tunable radioluminescence from green to orange-red, opening a new pathway toward recyclable, large-area, high-resolution, and color-visualized X-ray imaging platforms.
The study unveiled a novel regulation strategy that exhibits exceptional performance in gas sensing applications. This advanced material demonstrates outstanding selectivity, rapid response, and ultrahigh sensitivity, particularly in detecting ammonia (NH₃) molecules. The research, led by a team from East China University of Science and Technology, provides new insights into the gas sensing mechanisms of MXenes and introduces a synergistic strategy to optimize their performance.
The inherent structural instability and insufficient catalytic efficiency of enzymes may affect the reliability and sensitivity of enzyme-based immunosensors, especially in ultra-trace analysis. While covalent organic frameworks (COFs) offer excellent immobilization support due to their structural tunability and stability, conventional physical adsorption risks enzyme leakage, and their dense shells hinder mass transfer. Recent advances in defect engineering allow precise modulation of COF-enzyme interactions, enabling optimized enzyme conformation and activity, providing a promising platform for high-performance biosensors.
This study explores how healthy young adults’ brains adapt to visual occlusion during walking. Using Bangerter foils, resting-state functional magnetic resonance imaging (rs-fMRI), and pattern-reversal visual evoked potentials (PR-VEPs), it finds that walking activated key visuomotor pathways. Visual impairment strengthens functional connectivity between the right precentral and middle frontal gyri as compensation. The findings offer new potential targets for motor rehabilitation in low-vision populations.