In a study published in Science Bulletin, researchers from Tongji University led by Professors Yixuan Wang and Shaorong Gao constructed a novel in vitro model simulating the human preimplantation epiblast (EPI), primitive endoderm (PrE), and trophectoderm (TE) lineages. Through single-cell transcriptomic analysis and intercellular communication inference using CellChat toolkit, the team delineated the cell-cell communication landscape among tri-lineages.  Notably, they highlighted the critical role of secreted NRG signaling from EPI to TE, mediated by NRG1-ERBB3 axis, in regulating trophectoderm specification through the intracellular effector TFAP2C—a signaling axis validated in both trophectoderm induction system and human blastocyst development.

Recently, Hangzhou Institute of Medicine (HIM), University of Chinese Academy of Sciences (UCAS), Guangzhou National Laboratory and other research institutes published a perspective entitled Redefining imaging genomics for the next decade on Science Bulletin, in which the article systematically summarizes the existing advancements in imaging genomics, and proposes a framework for imaging genomics that provide a new path for precision medicine.

Breast cancer progression is driven by a complex ecosystem where cancer cells and their microenvironment communicate extensively. A recent Perspective article in Science Bulletin from a team led by Dr. Wenqian Wang (The Second Affiliated Hospital of Wenzhou Medical University), Professor Min Wu (University of Chinese Academy of Sciences, Wenzhou Institute), and Associate Professor Chunyan Hua (Wenzhou Medical University) reveals the crucial crosstalk between exosomes—small messengers released by cells—and metabolic reprogramming in breast cancer. This interaction influences tumor growth, resistance to therapy, and cancer stem cell survival. The study proposes innovative diagnostic and therapeutic strategies targeting this “exosome-metabolism axis”, offering new hope for more effective patient management.

China’s “double reduction” policy, launched in 2021, seeks to ease student stress by limiting homework and curbing off-campus tutoring. Early results show reduced anxiety and greater parent satisfaction, yet challenges remain. Teacher workloads have increased, resource gaps persist in rural schools, and underground tutoring continues. Sustained progress will require systemic reforms and collaboration among schools, families, and policymakers to ensure balanced, high-quality education for all.

Dr. Jin Wang from University of Chinese Academy of Sciences/ State University of New York at Stony Brook and Dr. Xiaona Fang from Northeast Normal University published an article titled “Identifying early warning signals of cancer formation” in the journal Quantitative Biology. Using theories of nonequilibrium potential landscape and steady-state probability flux, and indicators such as entropy production rate and mean flux derived from time-series gene expression data, they identified early warning signals during gastric cancer development, providing theoretical basis for early diagnosis.

Truncal acne differs from facial acne, with lower sebum/pH but greater microbial imbalance. Androgen levels, gender, and material contact influence outbreaks. The study evaluates treatment products' mechanisms, targets, and pros/cons, guiding clinical choices. These insights advance research and management strategies for truncal acne. 

Building on serum metabolites analysis in rosacea, researchers have identified linoleic acid (LNA) as a key therapeutic candidate, and further demonstrated that LNA prevents rosacea-like dermatitis in LL37-induced rosacea-like mouse model.

Researchers conducted comprehensive safety assessments on triazine UV filters ethylhexyl triazone (EHT) and diethylhexyl butamido triazone (HEB). Through bacterial reverse mutation, chromosomal aberration, micronucleus assays, and 3T3 phototoxicity tests, both compounds showed no genotoxic or phototoxic effects even at high concentrations. These findings support the safety of EHT/HEB for topical use in sunscreens, addressing regulatory concerns.

A thermal management scheme is designed in this paper that can be applied to 51.2 Tbit/s co-packaged optics (CPO), which successfully solved the heat dissipation difficulties of high-bandwidth co-packaged optics.