A team led by Professors Jianping Weng, Sihui Luo and Lianxin Liu from the University of Science and Technology of China published the study Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis in Science Bulletin.This study identifies the IFRD1-GLUD1-α-KG cascade as a vital link between metabolism and epigenetics. It establishes the first clinical association of IFRD1 with MASLD, reveals a GLUD1-dependent pathogenic pathway, and validates α-KG’s epigenetic function, offering a novel metabolism – epigenetics - targeted therapeutic strategy for MASLD.

By harvesting the energy destined for nonradiative decay and redirecting energy flux in dye-sensitized Er³⁺-based nanoparticles via an active shell (Yb³⁺), a three-order-of-magnitude enhancement at 1525 nm was achieved. The mechanistic insights and design principles inform the development of efficient NIR-II nanoprobes, demonstrating substantial potential for advancing vascular biology.

Precise high-speed motion tracking is vital for advanced manufacturing and robotics, yet existing methods force a trade-off between speed and directional accuracy. Now, scientists in China have developed a technique based on chirped power oscillation waves using dispersion-controlled dual-swept lasers. It achieves sub‑micrometer displacement precision at MHz update rates, and even reveals hidden mechanical vibrations in motion‑control equipment, opening a new path for smart ranging systems.

Supercontinuum is an important light-source for spectroscopy and fundamental science. However, on-chip ultraviolet supercontinuum sources have remained challenging due to absorption and dispersion of conventional photonic materials. A team at Zhejiang University demonstrated for the first time, an on-chip UV-C to mid-infrared (270–2400 nm) supercontinuum source using periodically poled lithium tantalate (PPLT) thin films, covering more than three octaves. This platform opens new avenues for broadband on-chip nonlinear photonics and spectroscopic sensing.