Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy. This retrospective cohort study investigates the real-world effectiveness and safety of olaparib, a PARP inhibitor, in patients with newly diagnosed advanced-stage, high-grade serous ovarian cancer who are HRD positive but BRCA wild-type, a demographic less extensively explored in previous research. The primary goal was to assess the 1-year progression-free survival (PFS) rate of olaparib maintenance therapy in this specific patient group, offering insights into its potential as a therapeutic option.

In the research, they investigate the reason for the long DNN model warm-up time in Web apps and find that compiling WebGL programs into binaries takes most of the time. Inspired by this finding, they propose WPIA, an approach that reduces the DNN warm-up time in Web apps by precompiling WebGL programs offline.

Jilin University-A new study published in the Journal of Science Bulletin proposed an innovative conceptual mechanism known as the “orbital stabilisation effect” for the precise design of novel Sb-based single-atom catalysts (SACs) to achieve high activity and ultra-long durability in the oxygen reduction reaction (ORR).

In a paper published in National Science Review, a bottom-up isoprene emission inventory, including both biogenic and combustion sources, was developed and used to model the contributions of isoprene to secondary organic aerosol formation in China. The results show that emissions of isoprene from combustion sources contributed substantially to ambient secondary organic aerosol, particularly during winter.

A new review published in the Journal of Bioresources and Bioproducts highlights the latest advancements in using biomass-based macroporous scaffolds for wound healing. The study, led by Daqian Gao from Yale University, explores sustainable alternatives to traditional polymers, focusing on the potential of biomass materials derived from renewable sources. These materials, which include cellulose, lignin, and starch, offer biodegradability and environmental friendliness while supporting tissue regeneration.

The analysis of over 6,400 research articles shows a significant rise in studies on hydrothermal pretreatment, with China leading the global research output. The findings underscore the potential of this green technology for converting lignocellulosic biomass into biofuels and bioproducts.

A new review article explores the development, challenges, and future potential of cellulose-based sutures, highlighting their potential to replace traditional fossil-based sutures in medical applications.

Researchers at Washington State University have developed a novel kinetic model called the Anaerobic Digestion Bacteria Algae (ADBA) model, which predicts the growth of algae and bacteria in anaerobic digestion effluent. This model offers insights into optimizing wastewater treatment and biofuel production.

A pioneering study has unveiled the transformative role of air-liquid interface (ALI) culture in the morphogenesis of hair follicles within skin organoids derived from human-induced pluripotent stem cells (hiPSCs).