Estrogen partially restores progesterone production and ovarian health in mice with lysosomal storage disorder
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-Jul-2025 05:10 ET (8-Jul-2025 09:10 GMT/UTC)
A recent study published in Reproductive and Developmental Medicine has revealed that estrogen can partially restore progesterone levels and improve ovarian health in Mcoln1−/− mice, which serve as a model for human mucolipidosis type IV (a type of lysosomal storage disorder). These mice have premature luteolysis leading to progesterone deficiency and infertility.
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