A novel mechanism based on Yinxie Granules and its core active ingredients (quercetin and kaempferol) to ameliorate psoriasis by blocking the STING-NF-κB signaling pathway to simultaneously suppress cutaneous inflammation and pathological angiogenesis is provided, and a new strategy for dual-targeting therapy of psoriasis is opened.

A research team demonstrated that pulsed electric field (PEF) processing can effectively inactivate harmful foodborne bacteria in bovine colostrum while potentially preserving its valuable immune-supporting compounds. 

Researchers have developed a series of Ce-doped BiOI catalysts via a one-pot solvothermal method for the cycloaddition of CO₂ with epoxides to produce cyclic carbonates. Ce doping facilitates the formation of oxygen vacancy-mediated Lewis acid-base pairs, where Oᵥ–Ce³⁺ sites enhance epoxide adsorption and ring-opening, while Bi–Oᵥ sites supply CO₂ adsorption sites. The optimized Ce₀.₁Bi₀.₉OI catalyst achieves a butylene carbonate yield of 91 % under solvent- and cocatalyst-free conditions, with an apparent activation energy of 70.67 kJ·mol⁻¹ – 35 % lower than that of undoped BiOI.

Researchers have developed a data-driven framework to analyze structure-performance relationships and identify optimal scale-up patterns for modular CO₂ reduction microreactors. Using extreme gradient boosting combined with SHAP analysis, the study reveals that cost is primarily governed by substrate-level features, while reaction performance and carbon footprint are dictated at the stack level. A classification model identifies Pareto-optimal designs with over 90 % accuracy, and K-means clustering uncovers four distinct scale-up patterns: small- and large-sized single-stack and few-stack parallel modules. These findings provide practical design rules for industrial-scale modular devices.

Researchers have systematically quantified temperature-induced measurement errors in electrical capacitance tomography for high-temperature gas-solids fluidized beds. Numerical simulations across a broad geometric matrix (outer diameters from 27 to 1067 mm) combined with high-temperature experiments reveal that while normalized sensitivity distributions remain exceptionally stable, raw capacitance measurements are highly susceptible to thermal perturbations. Crucially, increasing wall thickness drastically amplifies errors for adjacent electrode pairs. Excluding adjacent measurements effectively suppresses thermal deviations, extending the permissible operating range at the cost of fine-scale boundary resolution. A theoretical equivalence between thermal distortions and inherent noise enables direct application of noise-based criteria to define operational limits.

Researchers have developed hierarchical porous carbon nanosheets (CMK‑700) derived from coal tar pitch via a space‑confinement and activation strategy. The optimized material features a high specific surface area of 2223.9 m²·g⁻¹ and a maximized ultramicroporous volume of 0.4836 cm³·g⁻¹. A unique dual‑ion relay storage mechanism was unraveled: larger [Zn(H₂O)₆]²⁺ ions are stored in larger micropores (>1 nm), while smaller hydrated protons (H₃O⁺) act as “charge relays” to penetrate ultramicropores (<1 nm) via reversible chemical hydrogen adsorption/desorption. The assembled device delivers a specific capacity of 368.1 mAh·g⁻¹ at 0.5 A·g⁻¹ and retains 86.39 % capacity after 21,000 cycles.

Metabolic dysfunction-associated steatotic liver disease (MASLD), which affects about 30% of the population worldwide, is driven in part by excessive hepatic de novo lipogenesis (the production of fatty acids within the liver). In mice, the minor intron splicing factors ZRSR1 and ZRSR2 can influence hepatic lipid metabolism by controlling the processing of Insig transcripts. Whether these proteins also regulate metabolism independently of their canonical splicing function has remained unclear.