How can we fabricate an artificial brain that mimics the natural brain, from structure to function?

In response to this question, researchers from Xi’an Jiaotong University published a review paper outlining the primary requirements and challenges in biomanufacturing brain-like tissue, summarizing the existing technologies, strategies, and characteristics, and reviewing the cutting-edge developments in biomanufacturing central neural repair prosthetics, brain development models, brain disease models, and brain-inspired biocomputing models.

This review helps readers systematically understand the challenges, current progress, and future directions of brain-like living tissue manufacturing.

Plasmonic nanoantennas provide unique opportunities for precise control of light-matter coupling in surface-enhanced infrared absorption (SEIRA) spectroscopy, but most of the resonant systems realized so far suffer from the obstacles of low sensitivity, narrow bandwidth, and asymmetric Fano resonance perturbations. Here, we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient (µ) (OC-Hµ resonator) by precisely controlling the radiation loss channel, the resonator-oscillator coupling channel, and the frequency detuning channel. We observed a strong dependence of the sensing performance on the coupling state, and demonstrated that OC-Hµ resonator has excellent sensing properties of ultra-sensitive (7.25% nm^-1), ultra-broadband (3-10 µm), and immune asymmetric Fano lineshapes. These characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules, trace detection, and protein secondary structure analysis using a single array (array size is 100 × 100 µm²). In addition, with the assistance of machine learning, mixture classification, concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%. Finally, we demonstrated the potential of OC-Hµ resonator for SARS-CoV-2 detection. These findings will promote the wider application of SEIRA technology, while providing new ideas for other enhanced spectroscopy technologies, quantum photonics and studying light-matter interactions.

Lithium-ion batteries (LIBs) have dominated the portable electronic and electrochemical energy markets since their commercialisation, whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries (AIBs) including sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs). Owing to larger ion sizes of Na⁺ and K⁺ compared with Li⁺, nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium storage. With enticing open rigid framework structures, Prussian blue analogues (PBAs) remain promising self-sacrificial templates for the preparation of various nanocomposites, whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal decomposition. This review focuses on the recent progress of PBA-derived nanocomposites from their fabrication, lithium/sodium/potassium storage mechanism, and applications in AIBs (LIBs, SIBs, and PIBs). To distinguish various PBA derivatives, the working mechanism and applications of PBA-templated metal oxides, metal chalcogenides, metal phosphides, and other nanocomposites are systematically evaluated, facilitating the establishment of a structure–activity correlation for these materials. Based on the fruitful achievements of PBA-derived nanocomposites, perspectives for their future development are envisioned, aiming to narrow down the gap between laboratory study and industrial reality.

Two-terminal (2-T) perovskite (PVK)/CuIn(Ga)Se₂ (CIGS) tandem solar cells (TSCs) have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley-Queisser (S-Q) limits. However, the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device performances. In this paper, D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK crystals. In addition, the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination. A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain boundaries. Meanwhile, LiF is used to create this field effect, repelling hole carriers away from the PVK and C60 interface and thus reducing recombination. As a result, a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6% (0.16 cm²), one of the highest results for 2-T PVK/CIGS TSCs to our knowledge. This validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching, adjusting dielectric/magnetic resonance and promoting electromagnetic (EM) wave absorption, but still exist a significant challenging in regulating local phase evolution. Herein, accordion-shaped Co/Co₃O₄@N-doped carbon nanosheets (Co/Co₃O₄@NC) with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and low-temperature oxidation process. The results indicate that the surface epitaxial growth of crystal Co₃O₄ domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components, which are beneficial for optimizing impedance matching and interfacial polarization. Moreover, gradient magnetic heterointerfaces simultaneously realize magnetic coupling, and long-range magnetic diffraction. Specifically, the synthesized Co/Co₃O₄@NC absorbents display the strong electromagnetic wave attenuation capability of -53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz, both are superior to those of single magnetic domains embedded in carbon matrix. This design concept provides us an inspiration in optimizing interfacial polarization, regulating magnetic coupling and promoting electromagnetic wave absorption.

Abstract

Purpose – This paper explores the linkage of digital infrastructure to the cost of debt.

Design/methodology/approach – This study uses the implementation of the “Broadband China” policy that improves digital infrastructure as an exogenous shock and exploits the difference-in-differences method (DID).

Findings – Empirical analyses show that digital infrastructure leads to increased firms’ borrowing costs, which is robust to several robustness checks. In addition, we find that this unfavourable effect can be attributed to intensified market competition led by digital infrastructure construction. Cross-sectional analysis shows that this effect is greater for non-SOEs and smaller firms. Finally, we offer additional evidence of the unfavourable effect by showing that digital infrastructure construction leads to decreased fundamentals.

Originality/value – Our paper unveils how digital infrastructure construction affects firms’ business strategy in using private debts and extends the determinants of firms’ borrowing costs.

A groundbreaking study published in MedComm-Oncology reveals the critical role of adenosine phosphate signaling in shaping the tumor microenvironment (TME) and enhancing antitumor immunity. Led by researchers from Central South University, the study identifies distinct signaling subtypes in melanoma and develops a novel predictive model, APsig, which correlates with improved survival and responsiveness to immunotherapy. Through single-cell and spatial transcriptomic analyses, the team uncovers how this signaling pathway activates myeloid cells to drive antigen presentation, offering new targets for combination therapies with immune checkpoint inhibitors.

T cells exhibit remarkable plasticity in the tumor microenvironment (TME), dynamically adapting their phenotypes and functions to influence cancer progression and treatment responses. A new review published in MedComm-Oncology systematically dissects the mechanisms underlying T-cell plasticity, including spatial distribution, metabolic reprogramming, and interactions with TME components. The study highlights how targeting T-cell plasticity could revolutionize cancer therapy by enhancing immunotherapy efficacy and overcoming treatment resistance.