Tanshinones—the bioactive compounds responsible for the cardiovascular benefits of the traditional Chinese medicinal herb Salvia miltiorrhiza—accumulate at relatively low levels in the plant, limiting their therapeutic and commercial potential. 

Bone repair depends on skeletal progenitor cells (SPCs) moving to injured areas and developing into bone-forming cells, but how these cells respond to their surroundings remains unclear. A study published in the International Journal of Oral Science shows that two collagen receptors, β1 integrin and DDR2, work together to regulate SPC migration, proliferation, and differentiation during cranial bone regeneration. The findings reveal a cooperative mechanism that could guide strategies to enhance bone repair.

Digital pathology relies on high-resolution imaging for accurate cancer diagnosis, yet high-magnification systems remain slow and costly for large-scale screening. Meanwhile, standard AI super-resolution often generates hallucinated cellular artifacts that risk diagnostic accuracy. To overcome this, researchers developed a hybrid bright-dark field computational framework using fast LED illumination to provide physical guidance. This physics-guided approach doubles spatial resolution, reduces reconstruction artifacts by 84%, and boosts AI cancer screening sensitivity by 11.14%.

Researchers developed WiFo-2, a wireless foundation model for heterogeneous future wireless systems. Pretrained on 11.6 billion CSI points, it surpassed fully supervised task-specific models in three zero-shot reconstruction tasks and used 1% of labeled data for nine downstream tasks. Its confidence estimates support reliable operation. A prototype validated three tasks across indoor and outdoor scenarios and bands spanning sub-6 GHz and millimeter-wave.

Developing radiosensitizing agents to amplify tumor-eradicating effects on primary, regional recurrence, and distant metastases plays a transformative role in modern cancer care. Here, we report the de novo design of biocatalytic artificial metalloenzymes with an IrMn-cluster-based redox center (IMM) to achieve radiosensitized systemic antitumor responses for preventing malignant tumor metastasis and recurrence. Notably, our findings indicate that Mn-organic ligands substantially enrich the electron density of Ir clusters, thereby optimizing their interaction with oxygen species and markedly enhancing the production of both reactive oxygen species and molecular oxygen. When combined with radiotherapy, the IMM effectively amplifies DNA damage and induces pronounced apoptosis by alleviating intratumoral hypoxia. This shift reprograms the tumor microenvironment, enhancing radiosensitivity and facilitating the infiltration and activation of intratumoral CD8⁺ T cells and dendritic cells. Moreover, when integrated with anti-PD-1 therapy, this coordinated therapeutic regimen elicits potent systemic immune responses and durable antitumor memory, effectively suppressing tumor recurrence and metastasis while markedly improving therapeutic efficacy and long-term survival. We anticipate that this conceptual design could offer a promising and translationally relevant nanomedicine platform for radiotherapies.

A research team from Yantai University, in collaboration with the University of Tennessee, has uncovered why a precipitation-strengthened high-entropy alloy (HEA) that exhibits an excellent strength-ductility combination at 600 °C abruptly loses more than half of its strength when the temperature rises to 700 °C. Through stress-relaxation experiments combined with a direct comparison of stressed and strain-free regions within the same specimen, the team traced this catastrophic softening to a transition in the deformation mechanism near 650 °C: the dominant deformation mechanism shifts from dislocation climb to dynamic recrystallization (DRX) governed by grain boundary diffusion. The study establishes grain boundary stability under stress as a critical and previously overlooked design criterion for high-temperature structural alloys.

Greenland ice records human efforts to cut pollution. But after about 1990, different chemical pollutants diverge to different paths.