Data from a randomised controlled trial of iTBS in depression (n=82) were analysed using a data-driven approach to classify homogeneous subgroups based on the DMN. Connectivity subgroups were compared on depressive symptoms and cognitive function at pretreatment and post-treatment. Furthermore, the predictive significance of baseline inflammatory cytokines on post-treatment outcomes was evaluated.

This study is a 6-month pilot three-arm randomised controlled trial. Eligible participants (n=108) were recruited and randomised to the AE group, RE group or control (CON) group with a 1:1:1 ratio. Interventions were delivered at home with remote supervision. We evaluated participants’ global cognition, memory, executive function, attention, physical activity levels, physical performance and muscle strength of limbs at baseline, 3 months (T1) and 6 months (T2) after randomisation. A linear mixed-effects model was adopted for data analyses after controlling for covariates. Tukey’s method was used for adjusting for multiple comparisons. Sensitivity analyses were performed after excluding individuals with low compliance rates.

Increasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction (MI) or direct myocardial injury. Mental stress leads to systemic inflammation. Inflammation is known to cause rapid atheromatous plaque progression, instability and thrombosis—the classic type 1 MI. Inflammation can also lead to type 2 MI or myocarditis and injury. The published data linking systemic inflammation, mental stress and cardiovascular disease will be reviewed to establish the linkage between mind and heart, thereby highlighting the importance of holistically managing the patient, not only addressing separate organ systems. Finally, recent trial evidence showing the value of anti-inflammatory drugs in cardiovascular and mental conditions will be briefly considered.

Understanding how genes behave within their native tissue environment is unlocking new frontiers in medical science. 

In an era defined by uncertainty and rapid change, equipping students with entrepreneurial skills has become more urgent than ever. 

This research offers valuable insights into optimizing the structure of platinum-based catalysts to enhance their catalytic activity and stability. The ultra-low platinum loading ORR electrocatalyst developed in this study has the potential to significantly reduce the cost of fuel cells and zinc-air batteries, making them more viable for commercial applications. The findings pave the way for the development of more efficient and cost-effective energy conversion devices.

Brain-computer interface (BCI) technology is opening an unprecedented chapter in human-machine integration by establishing direct communication between the brain and external devices.

The color and texture of pear skin greatly influence its market value and consumer appeal. 

The advancement of artificial intelligence (AI) has ushered in a new era of automated robotics that are adaptive to their environments.   The field of robotics has made remarkable strides over the past few decades, yet it continues to face challenges that hinder the full utilisation of its potential. Traditional robots often rely on pre-programmed instructions and restricted configurations, limiting their ability to respond to unforeseen circumstances. AI technologies - encompassing cognition, analysis, inference, and decision-making-enable robots to operate intelligently, significantly enhancing their capabilities to assist and support humans. 

Plant genome editing through CRISPR-Cas holds transformative potential, yet its precision remains hampered by low gene targeting (GT) efficiency.