Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, and approximately 90% of cases are caused by progerin. Progerin is toxic and causes diverse abnormalities. More and more studies show that progerin is also detected in physiological aging and chronic kidney disease (CKD). Thus, targeting progerin clearance shows powerful potential for the treatment of HGPS, CKD and aging-related diseases. Now, Zhang group from Peking University and Kunming University of Science and Technology, reports that activating lysosome biogenesis can promote progerin clearance and alleviate cellular senescence in HGPS. They identify lysosome defects as a prevalent feature in HGPS, which impairs progerin clearance, and reveal that activating lysosome biogenesis can counteract lysosome defects and accelerate progerin clearance and mitigate DNA damage, cell cycle arrest, low proliferation ability and senescence-associated secretory phenotype (SASP) in HGPS cells. The findings highlight the vital role of lysosomes in progerin clearance, and uncover the potential of targeting lysosome biogenesis in anti-senescence.

Wide-temperature applications of sodium-ion batteries (SIBs) are severely limited by the sluggish ion insertion/diffusion kinetics of conversion-type anodes. Quantum-sized transition metal dichalcogenides possess unique advantages of charge delocalization and enrich uncoordinated electrons and short-range transfer kinetics, which are crucial to achieve rapid low-temperature charge transfer and high-temperature interface stability. Herein, a quantum-scale FeS₂ loaded on three-dimensional Ti₃C₂ MXene skeletons (FeS₂ QD/MXene) fabricated as SIBs anode, demonstrating impressive performance under wide-temperature conditions (− 35 to 65 °C). The theoretical calculations combined with experimental characterization interprets that the unsaturated coordination edges of FeS₂ QD can induce delocalized electronic regions, which reduces electrostatic potential and significantly facilitates efficient Na⁺ diffusion across a broad temperature range. Moreover, the Ti₃C₂ skeleton reinforces structural integrity via Fe–O–Ti bonding, while enabling excellent dispersion of FeS₂ QD. As expected, FeS₂ QD/MXene anode harvests capacities of 255.2 and 424.9 mAh g⁻¹ at 0.1 A g⁻¹ under − 35 and 65 °C, and the energy density of FeS₂ QD/MXene//NVP full cell can reach to 162.4 Wh kg⁻¹ at − 35 °C, highlighting its practical potential for wide-temperatures conditions. This work extends the uncoordinated regions induced by quantum-size effects for exceptional Na⁺ ion storage and diffusion performance at wide-temperatures environment.

Formamidinium lead iodide (FAPbI₃) perovskite exhibits an impressive X-ray absorption coefficient and a large carrier mobility-lifetime product (µτ), making it as a highly promising candidate for X-ray detection application. However, the presence of larger FA⁺ cation induces to an expansion of the Pb-I octahedral framework, which unfortunately affects both the stability and charge carrier mobility of the corresponding devices. To address this challenge, we develop a novel low-dimensional (HtrzT)PbI₃ perovskite featuring a conjugated organic cation (1H-1,2,4-Triazole-3-thiol, HtrzT⁺) which matches well with the α-FAPbI₃ lattices in two-dimensional plane. Benefiting from the matched lattice between (HtrzT)PbI₃ and α-FAPbI₃, the anchored lattice enhances the Pb-I bond strength and effectively mitigates the inherent tensile strain of the α-FAPbI₃ crystal lattice. The X-ray detector based on (HtrzT)PbI₃(1.0)/FAPbI₃ device achieves a remarkable sensitivity up to 1.83 × 10⁵ μC Gy_air⁻¹ cm⁻², along with a low detection limit of 27.6 nGy_air s⁻¹, attributed to the release of residual stress, and the enhancement in carrier mobility-lifetime product. Furthermore, the detector exhibits outstanding stability under X-ray irradiation with tolerating doses equivalent to nearly 1.17 × 10⁶ chest imaging doses.

The article highlights how integrated platforms—especially within scanning electron microscopes (SEM)—are enabling multi-degree-of-freedom, closed-loop nano-robots capable of precise assembly and manufacturing at the atomic scale. These advances pave the way for breakthroughs in quantum devices, nanomedicine, and advanced materials.

The translation of terahertz (THz) technology into clinical practice is hampered by the lack of endoscopic systems capable of THz-wave delivering to hard-to-access bio-tissues. Addressing this challenge, the authors begin with a brief overview of THz-based diagnosis of neoplasms. The article then reviews the two existing principles of THz endoscopy: the use of fiber-coupled photoconductive antennas and THz optical fibers. Finally, notable examples of THz endoscopic systems with different guiding mechanisms, material platforms, and manufacturing strategies are discussed.

Meta-holograms with nano-structured metasurfaces enable efficient light recording, offering high capacity for information storage and imaging. Scientists in China provided a full-modulation metasurface strategy for robust and scalable multi-dimensional multiplexing meta-holography. This metasurface allows independent and arbitrary control of amplitude, phase, and polarization of spatial light, enabling precise construction of multiplexed holograms. The method showcases a potential for optical information storage, transmission, and encryption applications.

Researchers in Russia have demonstrated that the use of a latex-based tissue adhesive during axillary lymphadenectomy significantly reduces the risk of seroma and lymphorrhea, shortens hospital stay, and accelerates the initiation of adjuvant therapy.

Surgeons in Vietnam successfully applied refinements to a little-used flap technique to reconstruct a patient’s thumb after a severe motorcycle injury. By preserving subcutaneous tissue and creating a safe arterial margin, the team improved blood flow, reduced complications, and restored nearly full thumb function within a year. Their preliminary case report suggests these refinements may make the reverse homodigital dorsoradial flap a more reliable option for thumb reconstruction.