Fabrication of cross-scale biomimetic 3D hydrogel scaffolds with thermo-mechanical optimized properties via femtosecond laser dual-wavelength dual-pulse regulation
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Oct-2026 07:17 ET (22-Oct-2026 11:17 GMT/UTC)
The fabrication of high-performance 3D hydrogel scaffolds for tissue engineering requires a balance between mechanical stiffness and structural integrity, yet single-wavelength femtosecond laser processing has struggled to achieve both simultaneously. A dual-wavelength dual-pulse strategy with optimized spatiotemporal coordination has now been applied to the preparation of three-dimensional hydrogel cell scaffolds, overcoming the inherent limitations of single-wavelength processing and enabling 20-layer bubble-free scaffolds with enhanced mechanical properties and in-situ nanoscale topography for improved cellular responses.
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