Diabetic wounds are complicated to heal due to factors such as infection, excessive inflammation, and impaired angiogenesis. Now, a groundbreaking, innovative hydrogel dressing has emerged, synthesized from the decellularized extracellular matrix of deer antler and a therapeutic metal-phenolic network. This multifunctional material opens up new prospects for chronic wound management by synergistically exerting antibacterial, antioxidant, and anti-inflammatory effects while promoting robust angiogenesis and tissue regeneration.

A research team has developed an innovative nanodrug platform, NP_β-lap+PRO, for precise non-small cell lung cancer treatment. This system combines NQO1 bioactivation therapy with PROTAC technology and overcome drug solubility and targeting limitations. The design features a PLGA nanoparticle core co-encapsulating β-lapachone and a PARP1-targeting PROTAC molecule, shielded by a pH-responsive gadolinium-tannic acid shell. The platform's paramagnetic properties enable MRI tracking of drug distribution. Experiments confirm effective tumor accumulation and pH-triggered drug release. In A549 models, the system induces PARP1 degradation, disrupts DNA repair, and amplifies β-lap-NQO1-reactive oxygen species production, resulting in enhanced DNA damage and apoptosis.

A multifunctional hydrogel (HRZn) was fabricated through in situ mineralization and dynamic crosslinking of HA, Rhein, and Zn²⁺, resulting in enhanced mechanical properties and sustained release of bioactive components. In vivo evaluations demonstrated its potent efficacy in accelerating the healing of S. aureus-infected deep burn wounds.

A novel catalyst featuring a unique Ni−O−Si interface, engineered through a dual-polymer modification, enables efficient urea production from carbon dioxide and nitrate waste. This breakthrough offers a sustainable, energy-saving alternative to the traditional, energy-intensive industrial process, achieving high yield, selectivity, and long-term stability under ambient conditions.

A new scientific review reveals how click chemistry—a highly efficient chemical approach—is transforming oncology by merging accurate diagnosis with precision therapy into a single system. 

Cancer immunotherapy has saved lives, but it often falls short due to off-target toxicity and weak tumor-specific immune responses. 

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition characterized by accelerated aging, severe vascular fragility, and reduced life expectancy. In a rare case study, researchers report a traumatic brain injury case in a 15-year-old adolescent with HGPS, where conventional management methods failed, owing to no curative therapies for HGPS and limited benefits from lonafarnib. The report concludes by stressing the need for improved multidisciplinary trauma care strategies when managing patients with HGPS.

Tumor cells exploit chemokine signaling to construct an immunosuppressive microenvironment that resists anti-tumor immune responses. A new review systematically maps the chemokine-receptor network in the tumor microenvironment and introduces a three-part “3D” targeting strategy: Decrease recruitment of suppressive cells (Tregs, MDSCs, TAMs), Develop effector T cell and NK cell function, and Dismantle physical and signaling barriers that exclude effectors from tumors. This framework ultimately provides a roadmap for precision combination immunotherapy to overcome immune evasion