A new study outlines a comprehensive framework leveraging AI and big data to combat illegal plant trade, addressing global biodiversity threats with technological innovation.

Marine animals have spent hundreds of millions of years evolving short protein fragments that fight microbes, calm inflammation, and tame tumors. A new review in the Chinese Journal of Natural Medicines maps how researchers are finally catching up: extracting these peptides at scale, decoding their structures with high-resolution mass spectrometry, and using AI to predict which ones might become drugs. The global market for marine peptides already tops USD 310 million, and the authors argue the next wave of therapies for hypertension, diabetes, cancer, and drug-resistant infections may come from the bottom of the food chain.

A new study reveals that many oral cancers are no longer driven by traditional risk factors like smoking or Human papillomavirus infection. Instead, they arise from internal DNA damage and possible microbial influences. By analyzing tumor mutation patterns, researchers identified a distinct subtype of oral squamous cell carcinoma marked by immune evasion and antibacterial responses. These findings reshape our understanding of oral cancer and open the door to more precise, targeted treatments in the future.

Single-nucleus RNA-seq atlas of equine skeletal muscle reveals donkey and horse distinct cell types, with species-specific age-related shifts in muscle fiber composition. The conserved upregulation pattern of LDHA reveals the critical role of propanoate metabolism in energy supply for equine locomotion. Cross-species transcriptomic comparison delineates a highly conserved atlas of skeletal muscle cell types.

Researchers developed an exosome-loaded microneedle patch that significantly accelerates oral ulcer healing. By enabling localized and sustained delivery, the patch reduces inflammation and promotes tissue regeneration. Multi-omics analysis reveals that the treatment works by modulating macrophage–epithelial interactions through the TSP-1/CD47/NF-κB signaling pathway.

Researchers found that a small change in 3D-printing settings can help produce better-fitting permanent dental crowns. Crowns printed at moderate angles performed best overall. Thinner layers improved accuracy and fit, while thicker layers produced more consistent results across repeated prints.

A new international study quantifies, for the first time, how data losses in ocean monitoring would severely degrade the ocean heat estimates that underpin weather prediction, El Niño forecasting, and fisheries management.

Quantum particles in imperfect or quasiperiodic environments may spread, become localized, or enter critical states with fractal wave functions. These behaviors can combine into seven fundamental localization phases, but a unified framework for all of them has been missing. A team led by Prof. Xiong-Jun Liu at Peking University has now developed a generic spin-1/2 quasiperiodic system that captures all the fundamental phases, proves three theorems, constructs new exactly solvable models, and proposes the implementation with ultracold atoms in optical Raman lattices.