This study highlights a practical formulation strategy to enhance the skin penetration of 10-hydroxy-2-decenoic acid (10H2DA), a key bioactive compound in royal jelly. By incorporating anionic cross-linked polymers, the authors achieved more than a tenfold increase in 10H2DA permeation compared with royal jelly extract alone. The study further confirmed epidermal penetration using DESI imaging mass spectrometry and demonstrated that higher skin hydration strongly promotes 10H2DA delivery. These findings emphasize that both formulation design and skin condition are critical for improving the dermal delivery of low-molecular-weight amphiphilic compounds.

Bacterial vascular diseases can turn hidden infections into rapid crop collapse because pathogens build protective biofilms inside plant water-conducting tissues. A new study presents a targeted strategy to break that shield from within. 

Researchers from Charité–Universitätsmedizin Berlin developed a unified multiplex immunofluorescence (mIF) platform applicable to formalin-fixed liver tissues, organoids, primary liver cells and liver-on-a-chip systems. By combining sequential antibody stripping with an open-source image-processing tool, CytoPrixm, the workflow enables multidimensional spatial phenotyping using standard fluorescence microscopy and commercially available reagents. The study lowers technical and financial barriers to spatial biology research and provides a scalable framework for investigating cellular interactions and disease microenvironments in hepatology.

A nationwide survey published in the Journal of Intensive Medicine provides a detailed overview of intensive care units (ICU) across mainland China. The study analyzed responses from intensivists working in hospitals across 31 provinces. It examined ICU capacity, workforce characteristics, disease patterns, and medical technologies. While treatments such as mechanical ventilation are widely available, advanced technologies like extracorporeal membrane oxygenation remain limited. The findings highlight regional disparities and offer insights for strengthening critical care planning.

A 31-year global analysis covering 204 countries shows the absolute burden of viral skin diseases has surged by over one-third since 1990, now affecting 84.7 million people annually. The study identifies children under 15 and older adults as the most vulnerable groups and reveals widening socioeconomic disparities, calling for targeted public health interventions to address inequities.

A 31-year global analysis covering 204 countries shows the absolute burden of viral skin diseases has surged by over one-third since 1990, now affecting 84.7 million people annually. The study identifies children under 15 and older adults as the most vulnerable groups and reveals widening socioeconomic disparities, calling for targeted public health interventions to address inequities.

A parallel deep reinforcement learning framework for wind-solar-hydrogen systems cuts operational costs by 6% and accelerates training over fivefold, offering a scalable pathway to low-carbon grids.

We report a lattice-bulk regulation strategy for single-crystalline LiNi_0.92Co_0.04Mn_0.04O₂ (SNCM) cathodes by doping B/Zr to tackle instability and boost electrochemical performance.

Inspired by the triangular morphology of papyrus, researchers developed a biomimetic lattice metamaterial that redistributes stress from nodes to struts, achieving up to 63% increase in compressive strength and 32% enhancement in energy absorption.

As digital twins expand across fields ranging from healthcare to climate forecasting, concerns about privacy, cybersecurity, and transparency are also growing. A review of nearly 22,500 publications argues that digital twins should be understood as decision infrastructures that integrate sensing, modeling, artificial intelligence, and data systems to support smarter, more explainable, and secure decisions in complex real-world settings