This breakthrough research from Shanghai Jiao Tong University overcomes critical barriers to silicon micro-ring resonator (MRR) commercialization. By heterogeneously integrating low-loss phase-change material Sb₂Se₃, the team created non-volatile, "smart-programmable" transceivers enabling precise, full-spectral-range wavelength tuning via electrical pulses. Crucially, the technique preserves high performance, achieving 100 Gbps per MRR (400 Gbps total for 4 cascaded rings) and introducing an innovative thermal compensation scheme for stability. This work provides a robust solution for high-density, low-power optical interconnects, accelerating MRR technology from the lab towards transformative applications in data centers and high-speed networks, while showcasing the power of multidisciplinary innovation.

Gene delivery is a key area in biomedicine, where nucleic acids are delivered into cells to treat diseases by modulating genes. The low micelle concentration, effective nucleic acid complexation, and low immunogenicity make Gemini surfactants promising gene delivery vectors. Recently, a paper published in MedComm-Future Medicine summarizes strategies to improve the transfection efficiency or biocompatibility of Gemini surfactant vectors and explores their delivery mechanisms, thereby offering new insights into the field's development.

Research on the optical coherence manipulation has made significant progress, but the modulation rate of conventional tailoring technology is too low, which has become a key factor hindering its transition from laboratory to practical application. Here, we utilize lithium niobate films (LNF) modulator to achieve high-speed optical coherence manipulation based on its high-speed electro-optical modulation capability. Our experimental modulation rate reaches 350 kHz, which is about 20 times higher than the fastest modulation rate reported so far. This design strategy provides a simple rule for high-speed optical coherence manipulation based on electro-optical modulation, paving the way for further practical applications of optical coherence manipulation technology.

Achieving high efficiency, long operational lifetime, and excellent color purity is essential for organic light-emitting diode (OLED) materials used in next-generation display and lighting technologies, but these performance goals are increasingly difficult to reach with conventional trial-and-error design methods. In a new review published in Science Bulletin, researchers from Beijing Jiaotong University and Sichuan University present "Integrating AI into OLED Material Design: A Comprehensive Review of Computational Frameworks, Challenges, and Opportunities." The paper discusses how artificial intelligence (AI) can help overcome the limitations of traditional approaches, accelerate OLED material discovery, and offers a practical multi-level framework to guide future research in this field.

Research teams from Zhaoqing University and South China Normal University have provided an overview of the development of metal-organic framework (MOF)-derived lithium-ion battery (LIB) cathode materials. By the use of the MOF-mediated approach, the multiscale design of LIB cathodes from morphology, composition, and atomic/electronic configuration can be realized, resulting in a significant enhancement in lithium storage. This review provides valuable insights into the directional design of next-generation LIB cathodes.

Focusing on the research progress of electro-synthetic value-added chemicals, this comment proposes lab strategies to enhance energy conversion efficiency, including catalyst screening, process monitoring, interface optimization, and mass transfer design, with analysis of implementation challenges. It also emphasizes that for industrial application of electrosynthesis technology, breakthroughs are needed in performance, lifespan, and cost, and multidimensional challenges such as modular integration, thermal and mass management, smart control, power configuration, and material separation must be addressed.

Extreme environments demand smarter sensors! A team from Zhejiang University has developed a laser-induced, in-situ fabrication method for thin-film temperature sensors with no complex layering, no extra coatings.

💡 Their approach forms conductive & antioxidative layers simultaneously, enabling real-time monitoring from −50 °C to 950 °C with remarkable stability.
📈 Just 1.2% drift over 20 hours under heat, shock, wear, and vibration.

Tuberculosis (TB) belongs to infectious diseases leading to the high mortality and morbidity worldwide. Since long-term bacilli burden leads to metabolic disorders in TB patients, metabolic biomarkers with diagnosis and prognosis potential are worthy of elucidation. In this study, 1H nuclear magnetic resonance spectroscopy (1H NMR)-based plasma metabolomics were investigated dynamically in onset TB patients undergoing conventional anti-TB chemotherapy before and along with the treatment. We found that metabolomic profiles altered before and after the treatment of 2 and 4 months, among which four amino acids, including 4-aminobenzoate, phenylalanine, serine, and threonine, were screened out with significant decrease at 6 months after anti-TB therapy in the training longitudinal samples and validated in another longitudinal samples. Moreover, we have also confirmed the increase of 4 amino acid contents in the periphery of active TB patients when compared to those in healthy controls (HCs). Receiver operating characteristic (ROC) analysis revealed that the combination of 4 amino acids was able to distinguish TB patients from HC with an area under the curve (AUC) value of 0.912 ± 0.031 (P < 0.0001). Therefore, our study has identified an amino acid panel with increased levels in active TB patients and declined along with conventional anti-TB treatment, which might be potential in distinguishing TB patients from HCs as well as prognosis candidates in clinics.

Objective: To describe the case of V. ​vulnificus infection and to review the literature, emphasizing the importance of laboratory pathogen biology examination in clinical diagnosis and treatment. Methods: A retrospective review and analyzed a case of a patient infected with septic shock secondary to V. ​vulnificus due to trauma in Nanfang Hospital, Southern Medical University on August 9, 2023. This includes an examination of the symptoms, laboratory results, and treatment process. The BD Phoenix-M50 automatic bacterial identification analyzer was used to identify and test the susceptibility of cultured bacteria, the French Mérieux VITEK® MS IND MALDI TOF was used for identification by mass spectrometry. Results: Skin secretion culture and blood cultures are Vibrio vulnificus bacteria, according to select sensitive antimicrobial drug susceptibility results and surgical treatment after calcitonin original and CRP in patients with infective index returned to normal. Conclusions: Vibrio vulnificus can infect humans through damaged skin and cause wound infection and bloodstream infection. Early wound culture and blood culture are must. Early surgical operation combined with anti-infection therapy is the key to the treatment of Vibrio vulnificus infection to prevent secondary infection endangers the patient’s life. In addition, publicity and education such as preventive measures can also effectively reduce the infection rate of vibrio vulnificus.