According to research published in Angewandte Chemie International Edition recently, a team led by Prof. HU Linhua. from Hefei Institutes of Physical Science of the Chinese Academy of Science develop a high mechanical durability hydrogel electrolyte using urea as a zincophilic solubilizer and Zn(Ac)₂ salt for its low cost and eco-friendly traits. As-prepared hydrogels can sustain 557% tensile elongation and 3.7 MPa compressive strength. In-situ polyurea solid electrolyte interphase (SEI) formed during aqueous zinc-ion batteries (AZIBs)  operation allows for stable Zn stripping/plating in a dendrite and passivation-free manner.

Recently, Prof. JIANG Changlong’s research team from the Institute of Solid State Physics, the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, used multi-emission metal organic framework hydrogel (Eu-Dy MOF gel) to construct a non-invasive wearable eye patch fluorescence sensor, combined with the color recognition function of a smartphone to analyze and monitor lysozyme in tears. 

A research team led by Prof. SUN Youwen from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has developed two innovative artificial intelligence (AI) systems to enhance the safety and efficiency of fusion energy experiments. 

A research team led by Prof. SHAO Dingfu from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has predicted a new class of antiferromagnetic materials with unique cross-chain structures, termed  "X-type antiferromagnets". These materials exhibit sublattice-selective spin transport and unconventional magnetic dynamics, offering new possibilities for next-generation spintronic devices.

A research team led by Prof. SHAO Dingfu at the Institute of Solid State Physics, the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has unveiled a new mechanism for achieving strong spin polarization using antiferromagnetic metal interfaces. 

A research team led by Prof. GU Hongcang and ZHANG Fan from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has identified a novel long non-coding RNA (lncRNA)-driven regulatory network that plays a central role in colorectal cancer (CRC) progression and immune response. 

We’re thrilled to announce the launch of Biocontaminant, a multidisciplinary journal dedicated to tackling biocontamination and its impacts on sustainable development and global health. From pathogens and toxins to invasive species and antimicrobial resistance – this journal explores the critical challenges threatening our SDGs.

Objective

The concentration of bilirubin in blood or serum is useful for assessing liver function as well as monitoring treatment. This study evaluates the clinical performance of a novel point-of-care (PoC) device for the detection of bilirubin in serum. The PoC device incorporates an integrated miniature optoelectronic sensing module and a microfluidic test cartridge.

Methods

Patients’ serum total bilirubin concentrations, ranging from 2 ​μmol/L to 480 ​μmol/L, were measured using the PoC device and the standard laboratory method (n=20). Bland-Altman analysis and regression analysis using Passing-Bablok method were used to benchmark the PoC device against the standard laboratory measurements. The diagnostic capability of the PoC device in categorising the serum samples within clinically relevant bilirubin concentration thresholds of 200, 300, and 450 ​μmol/L was assessed using receiver operating characteristic (ROC) analysis.

Results

The mean difference between the PoC device and the standard laboratory method was −5.6 ​μmol/L, with a 95% confidence interval (CI) of −45.1 ​μmol/L to 33.9 ​μmol/L. The coefficient of determination (R²) was 0.986. The PoC device achieved a detection sensitivity of 90% and specificity of 97% in categorising bilirubin concentrations within bands used in clinical decision-making.

Conclusions

This study demonstrates that the proposed PoC device is capable of measuring bilirubin levels in patient samples with clinically acceptable accuracy.

Objective

Children with autism spectrum disorder (ASD) had lower vitamin D3 levels than neurotypical (NT) children, as well as deficits in language, social, and fine motor abilities. Nanotechnology has appeared as a suitable answer to absorption and bioavailability problems related to vitamin D3. This study aims to investigate the influence of vitamin D3-loaded nanoemulsion supplementation on adaptive behavior and language performance in children with ASD compared to the influence of the marketed product of vitamin D3.

Methods

Supplementation of ASD children with an oral vitamin D3-loaded nanoemulsion was performed in group I while the marketed product of the oral vitamin D3 was used in group II for 6 months. Evaluation of their abilities and measuring the plasma levels of 2 types of vitamin D3 were performed using ultra-performance liquid chromatography before and after supplementation.

Results

Supplementation in group I (n ​= ​40) has led to an elevation of levels of 25 (OH) and 1, 25 (OH)₂ forms of vitamin D3 (P ​< ​0.000,1), to behavioral improvement in the form of a reduction in ASD severity, and to a rise in the social IQ and total language age of ASD children (P ​= ​0.000,2, 0.04, 0.000,9, respectively). On the other hand, group II (n ​= ​40) did not show adaptive behavioral improvements.

Conclusions

The vitamin D3-loaded nanoemulsion provided better vitamin D3 bioavailability and a true influence on severity, adaptive behavior, fine motor abilities, and language performance, reflecting the desired benefits of the rise of vitamin D3 levels in the blood.

The study investigates the interaction between the human epidermal growth receptor 2 (HER2) and amygdalin, a compound found in peaches, almonds, and apples. To assess the potential of amygdalin, the interaction between HER2 and amygdalin was explored using molecular docking and molecular dynamics simulations. Binding energies were evaluated for both the crystal and equilibrated HER2 structures. The effects of water on binding were also assessed. Molecular dynamics simulations analyzed structural changes in HER2, including interdomain distances, hydrogen bond fluctuations, dihedral angle shifts, and residue-residue distances at the dimerization arm. The free energy landscape was constructed to evaluate stability. Binding energies of −33.472 ​kJ/mol and −36.651 ± 0.867 ​kJ/mol were observed for the crystal and equilibrated HER2 structures, respectively, with water further enhancing binding to −41.212,4 ​± ​1.272,7 and −53.513 ± 1.452,3 ​kJ/mol. Molecular dynamics simulations revealed significant conformational changes in HER2, including a reduction in interdomain distance, fluctuations in hydrogen bond lengths, and a shift in dihedral angles from 60° to −30°. The residue-residue distance at the dimerization arm decreased, indicating conformational changes upon binding. The free energy landscape showed a deeper and more defined minimum in the bound state, reflecting enhanced stability. These findings highlight amygdalin’s potential as a therapeutic agent targeting HER2.