New guidance on the management of aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer
Peer-Reviewed Publication
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An updated joint position statement on the management of aromatase inhibitor-associated bone loss (AIBL) addresses the heightened fracture risk in women undergoing endocrine therapy for estrogen-responsive breast cancer, providing practical guidance for both osteoporosis specialists and oncologists. Aromatase inhibitors are a cornerstone of adjuvant treatment for hormone-responsive breast cancer, significantly reducing the risk of recurrence. However, they also accelerate bone resorption, leading to a higher incidence of osteoporosis and fractures. Updating recommendations from 2017, the statement is by experts from the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG. It incorporates information from recent clinical trials, systematic reviews, and meta-analyses. Also, it provides a treatment algorithm to assess fracture risk and guide bone-directed therapy in women receiving aromatase inhibitors.
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