This study reveals that dynamin 1 (DNM1) promotes N-cadherin recycling through caveolae-mediated endocytosis, maintaining epithelial-to-mesenchymal transition (EMT) plasticity and driving ovarian cancer metastasis. DNM1 deficiency disrupts N-cadherin/Rab11 co-localization, while β-1,3-galactosyltransferase 1 (B3GALT1) inhibits this process. Clinically, elevated DNM1 expression correlates with poor prognosis in high-grade serous ovarian cancer and enhances nanoparticle uptake, providing a novel therapeutic target.

This study investigates the potential of the African swine fever virus (ASFV) p15 protein as an immunogen for developing vaccines against ASF. Researchers identified a high-affinity neutralizing antibody, 4E2, against p15 and elucidated the structure of the p15-4E2 complex. They also constructed two types of virus-like particles (VLPs) displaying p15 and evaluated their protective efficacy in pigs challenged with a moderately virulent ASFV strain.

This review discusses the evolution, challenges, and innovations of antibody-drug conjugates (ADCs) in cancer treatment. It focuses on the importance of precise target selection and engineering to improve efficacy while minimizing off-target toxicities. Recent advances such as pH-dependent antibodies, dual-epitope targeting, and AI-guided profiling are highlighted as promising strategies to enhance safety and therapeutic impact.

Researchers found a new adverse outcome pathway (AOP) for locomotor impairment initiated by TDCPP binding to integrin α_vβ₃ and established a quantitative response-response relationship linking integrin α_vβ₃ and locomotor impairment. These results further deepen the understanding of organophosphate esters -induced neurodevelopmental toxicity and thus provide a basis for the development of new AOPs.

This study reports two cryo-EM structures of the Nipah virus (NiV) polymerase L-P complex in its full-length and truncated forms. These structures elucidate the RNA-dependent RNA polymerase (RdRp) and polyribonucleotidyl transferase (PRNTase) domains of the L protein, as well as the tetrameric P protein bundle bound to the L-RdRp. This work establishes a foundational framework for understanding the NiV polymerase mechanism and provides critical insights for the rational design of antiviral therapeutics targeting the polymerase complex  

This perspective highlights the critical role of region-specific gut microbial distribution across intestinal segments (e.g., duodenum, colon) in regulating host metabolism and immunity, challenging traditional fecal-centric approaches. It emphasizes bile acid metabolism and small intestinal bacterial overgrowth (SIBO) in metabolic diseases like diabetes, proposing targeted interventions such as duodenal mucosal resection and probiotics to restore microbial niches. The study underscores AI-driven strategies for precision therapies addressing spatial microbial dynamics, offering novel pathways for disease therapeutics