The genetic risk of disease, not remission status, determines overall survival of patients with high-risk acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, there is no benefit of remission induction with standard salvage chemotherapy prior to allo-HSCT. These are the results of a recently published long-term follow-up [1] of the ASAP trial [2], which was conducted at renowned universities and clinics across Germany. “Our groundbreaking results once again demonstrate the importance of early stem cell transplantation and challenge international therapy standards,” says Prof. Dr. Johannes Schetelig, Head of the Stem Cell Transplantation Unit at the University Hospital Carl Gustav Carus Dresden and Director Clinical Research at DKMS who acted as the coordinating investigator of this clinical trial, which was financed and organized by DKMS. The international non-profit organization, dedicated to fighting blood cancer and recruiting stem cell donors worldwide, is committed to advancing research and development to improve therapies in the context of hematological diseases.

A new laser-based technique targets pancreatic ductal adenocarcinoma (PDAC) while leaving healthy tissue intact. 

The National Comprehensive Cancer Network^® (NCCN^®)—a nonprofit responsible for globally utilized guidelines for cancer care—shares new NCCN Guidelines Navigator™ resources for breast cancer treatment as well as genetic/familial high-risk assessment, during Breast Cancer Awareness Month.

When the nerves connected to taste buds are cut, the buds usually wither and later regrow. But Korean researchers found that not all taste cells fade equally. Sweet-sensing cells, supported by the protein c-Kit, are uniquely resilient. Using mouse and organoid experiments, the team showed that blocking c-Kit with the cancer drug imatinib eliminated these survivors, preventing regeneration. The discovery reveals how specific cell types drive taste recovery.

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from spreading. Researchers have discovered that an enzyme called EZH2 drives TNBC cells to divide abnormally, which enables them to relocate to distant organs. The preclinical study also found drugs that block EZH2 could restore order to dividing cells and thwart the spread of TNBC cells.

Researchers from Aarhus University have uncovered how cells in the cervix actively detect and combat infections. Using patient-derived mini-organs and advanced single-cell mapping, the study reveals a complex, coordinated defense network against pathogens like chlamydia. The findings pave the way for vaccines and treatments that boost local immune responses. The research is published in the scientific journal Science Advances.